Abstract:

OBJECTIVE： Angiotensin Ⅱ, except typical roles, can serve as a multieffect growth factor to affect the proliferation, necrosis and differentiation of cells, and participate in the self-repair of normal skin and injury repair, In the present study, we clarified the biological characteristics of types 1 and 2 Angiotensin Ⅱ and their roles in the repair of skin injury, DATA SOURCES： Pubmed was searched with computer for English articles about angiotensin Ⅱ and repair of skin injury published between January 1990 and January 2005 by using keywords “Angiotensin Ⅱ, skin”. Meanwhile, a computer-aided search of CNKI was carried out for the relevant Chinese articles published between January 1995 and May 2005. STUDY SELECTION： About 350 articles were selected firstly. The articles wero eligible and enrolled, if they were about biological characteristics of angiotensin Ⅱ and the role and mechanism in repair of skin injury and were randomized, controlled and blind studies. Articles about Meta analysis, review and repetitive studies were excluded. DATA EXTRACTION： Totally 80 articles related to biological characteristics of angiotensin Ⅱ and repair of skin injury, especially those related to the latter. Articles with similar content and published in authoritative journals in the past five years were enrolled firstly. Only 25 articles accorded with the criteria and were analyzed. DATA SYNTHESIS： Most researches on biological characteristics of angiotensin Ⅱ are associated with organs except skin tissue. Researches on angiotensin Ⅱ and repair of injured skin tissue, as a new investigation, obtain more and more attention, though there are many articles about angiotensin Ⅱ and injury repair of beart, brain, kidney, blood vessels and related disease onset. Trial evidences come from cell culture, animals and human body. CONCLUSION： Angiotensin Ⅱ, as a hormone and local multi-effect growth factor, influences the self-repair of skin and repair of injury skin tissue, h is beneficial to the further study on the molecular mechanism of wound healing and providing new ideas for treatment of refractory wound and scar through investigating the role and mechanism of angiotensin Ⅱ in skin repair.[著者文摘]