Abstract:

AIM：To summarize the source of neural stem cells and the development of neural stem cell transplantation for Parkinson disease. METHODS： Database of Chinese Scientific and Technical Periodicals was undertaken to identify the relevant articles on neural stem cell transplantation and Parkinson disease published from January 1994 to June 2007 with the key words of ＂neural stem cell transplantation, Parkinson disease＂ in Chinese. The data were primarily checked and quotation of each article was read. Articles on neural stem cell transplantation and Parkinson disease were included, and articles those wore published in recent 5 years in authoritative journals were firstly selected. Articles with repetitive content or Meta analysis were excluded. RESULTS： ①Neural stem cells have a strong potential of proliferation and movement and can replace injured brain cells. After proliferation, neural stem cells differentiate into nigral dopaminergic neurons in the host brain. ②Neural stem cells combined with gene therapy can inhibit neuronal degeneration and recover its function. ③Glial cell line derived neurotrophic factor and tyroxine hydroxylase can elevate the nigral dopamine levels, prolong the survival of nigral dopaminergic neurons, prevent the degeneration of nigral dopaminergic neurons and reestablish host nervous pathway. ④Neural stem cells are as a gene carder. Neural stem cell transplantation combined with polygene therapy provides a new approach for Parkinson disease. CONCLUSION： With the development of neural stem cell studies, neural stem cell transplantation becomes the main method to treat Parkinson disease.[著者文摘]