学术
摘 要:
目的分析描述胃食管反流病（GERD）患者的胃肌电活动特点,探讨胃动力障碍在GERD发病中的作用,以期有助于临床诊疗。方法对65例GERD患者和30例健康志愿者进行餐前、餐后体表胃电图监测,据内镜检查结果,把GERD患者分为反流性食管炎（RE）组、非糜烂性反流病（NERD）组,行组间胃电参数比较,随访19例胃电节律异常GERD患者,观察治疗前后胃电参数的变化。结果GERD组的主频（DF）正常慢波节律百分比（N%）、餐前餐后功率比（PR）与对照组相比明显降低（P〈0.05或0.01）,胃电节律紊乱,以胃动过缓为主。经1周治疗后,GERD异常胃电参数明显正常化（P〈0.05或0.01）。餐前RE组胃电节律异常的发生率（37.5%）显著高于NERD组（12.1%）。餐后胃电节律异常的发生率RE组和NERD组分别为71.9%和60.6%,两者没有统计学意义（P〉0.05）。结论GERD患者存在餐前、餐后胃肌电活动异常,异常胃电节律以胃动过缓为主,胃动力障碍参与了GERD的发病,EGG对GERD诊断和治疗具有一定的指导意义。[著者文摘]
文章出处:
《黑龙江医学》-2007年31卷10期 -733-735页
栏目信息:
分 类 号:
文献标识码:
A
文章编号:
1004-5775（2007）10-0733-03
Clinical Study of on Gastric Dysmotility in Patients with Gastroesophageal Reflux Disease
AN Peng, FAN Hong, CHEN Yan- min, et al . （ Department of Gastroenterology, The First People＇ s Hospital of Yunan Province, Kunming 650032, China ）
Abstract:
Objective Our aim was to investigate the behavior of gastromyoelectrie in patients with gastroesophaeal reflux disease （GERD）, and the effect of gastric dysmotility in pathogenesis of GERD. Methods 65 pat/ents with GERD were randomly chosen in this study.30 healthy Volunteers were used as normal control.All the patients and volunteers underwent fasting and postprandial electrogastrogram （EGG） examination. Patients with GERD were divided into 2 groups according to the result of gastroscopy：reflux esophagitis（RE） group and non- erosive seflux disease （NERD） group, The prevalence of gastric dysrhythmias were compared between the two groups. 19 patients with gastric dysrhythmia underwent the second ECG examination after one week＇s treatment. The EGG parameters were analyzed before and after the treatment.Results Compared with control group,dominant Frequency （DF） ,DF in normal range （N%） and posprandial to fasting power ratio （PR） were obviously decreased, especially after test meal （ P 〈 0.05 or 0.01 ）. Gastric electrical rhythm in GERD was disordered, and mainly displayed as bradyastria. The clinical symptoms were alleviated or disappeared in our clinical trial. At the same time, the EGG parameters of 19 patients with gastric dysrhythmia were improved significantly after the therapy （ P 〈 0.05 or 0.01）. The prevalence of preprandial gastric dysrhythmia in RE group was higher than that in GERD group （37.5% vs 12.1%, P 〈 0.05）.qlae prevalance of postprandial gastric dysrthythimia were 71.9% in RE group and 60.6% in NERD group. But,there was no statistical difference （ P 〉0.05）. Conclusion There were abnormal preprandial and postprandial gastric electrical activities in patients with GERD. Gastric dysmotility may play an important role in the Pathogenesis of GERD. Electrogastrogram can provide guide for diagnosis and therapy for GERD.[著者文摘]
Key words:
Gastroesophaeal reflux disease; Electrogastrography; Gastric dysrhythmia
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