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Synthesis of aromatic-linked polyamine macrocyclic derivatives as HIV-1 entry inhibitors
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Jing Su[1] Yao Liu[2] Zhi Bing Zheng[3] Jun Hai Xiao[3] Hong Lu[4] Wu Zhong[3] Li Li Wang[3] Shi Bo Jiang[4] Song Li[3]
[1]School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China [2]School of Pharmacy, Jilin University, Changchun 13002-1, China [3]Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China [4]Lindsley E Kimball Research Institute, the New York Blood Center, New York, NY 10021, USA
国际标准刊号：ISSN 1001-8417
国内统一刊号：CN 11-2710
文章出处:
《中国化学快报：英文版》-2007年18卷10期 -1166-1168页
Chinese Chemical Letters
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Synthesis of aromatic-linked polyamine macrocyclic derivatives as HIV-1 entry inhibitors
Abstract:
A series of novel aromatic-linked polyamine macrocyclic derivatives have been synthesized. Their structures were confirmed by MS and ^1H NMR. These compounds exhibited potent anti-HIV-1 activities.[著者文摘]
Key words:
HIV-1 entry inhibitors; Aromatic-linked polyamine; Macrocyclic derivatives; Synthesis
收稿日期: 2007-06-13
基金资助:
This work was supported by the National Basic Research Program of China （973 project： No. 2004CB518908） and the National Natural Science Foundation of China （No. 30472093） to SL and the 0utstanding 0verseas Chinese Scholars Fund of Chinese Academy of Sciences （No. 2005-2-6） to S.J.
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