基于形成复合物的中性分子LC-ESI-MS-MS方法发展
Changyu Quang Geralyn Kocan Daniel Tang Douglas M.Fast Steven M.Michael
摘 要:
对于极性与可带电分子而言,电喷雾离子化(ESI)是一种合适的质谱离子化模式,但由于非极性与中性分子的离子化效率低,一般不能直接采用ESI的离子化模式。为了克服电喷雾离子化的这种限制,已经发展了多种相应的策略,本文介绍的方法便是其中一种。这种方法采用一个小的阴离子与中性分子形成复合物,可以有效提高中性分子的电喷雾离子化能力。[著者文摘]
文章出处:
《生命科学仪器》-2007年5卷5期 -6-11页
Life Science Instruments
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相关文章:
Development of an LC-ESI-MS-MS Method With Formate Anion Attachment for Detecting Neutral Molecules in Rat Plasma
Changyu Quang, Geralyn Kocan, Daniel Tang, Douglas M. Fast, and Steven M. Michael
Abstract:
ESI is a suitable ionization mode for polar and chargeable molecules, its application to nonpolar and neutral molecules challenging because of their poor ionization efficiency. Various strategies have been developed to overcome the limitations of ESI, one of which is described in this paper. The procedure employs the attachment of a small anion to neutral molecules, which renders them ionizable with ESI.[著者文摘]

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