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HIV-1 can infect northern pig-tailed macaques (Macaca leonina) and form viral reservoirs in vivo

《科学通报:英文版》2017年 第19期 | Wei Pang Gao-Hong Zhang Jin Jiang Hong-Yi Zheng Lin-Tao Zhang Xiao-Liang Zhang Jia-Hao Song Ming-Xu Zhang Jia-wu Zhu Ai-Hua Lei Ren-Rong Tian Xiao-Ming Liu Liguo Zhang Guangxia Gao Lishan Su Yong-Tang Zheng   Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yannan Province Kunming Institute of Zoology Chinese Academy of Sciences Kunming 650223 China University of Chinese Academy of Sciences Belting 100091 China Key Laboratory of Infection and Immunity Institute of Biophysics Chinese Academy of Sciences Belting 100101 China South China Institute of Endangered Animal Guandong Academy of Sciences Guangzhou 510260 China Department of Microbiology and Immunology School of Medicine The University of North Carolina at Chapel Hill NC 27599-7290 USA Institute of Health Sciences Anhui University Hefei 230601 China
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摘 要:Viral reservoirs of HIV-1 are a major obstacle for curing AIDS. The novel animal models that can be directly infected with HIV-1 will contribute to develop effective strategies for eradicating infections.Here, we inoculated 4 northern pig-tailed macaques(NPM) with the HIV-1 strain HIV-1_(NL4.3) and monitored the infection for approximately 3 years(150 weeks). The HIV-1-infected NPMs showed transient viremia for about 10 weeks after infection. However, cell-associated proviral DNA and viral RNA persisted in the peripheral blood and lymphoid organs for about 3 years. Moreover, replication-competent HIV-1could be successfully recovered from peripheral blood mononuclear cells(PBMCs) during long-term infection. The numbers of resting CD4~+T cells in HIV-1 infected NPMs harboring proviruses fell within a range of 2-to 3-log_(10) per million cells, and these proviruses could be reactivated both ex vivo and in vivo in response to co-stimulation with the latency-reversing agents JQ1 and prostratin. Our results suggested that NPMs can be infected with HIV-1 and a long-term viral reservoir was formed in NPMs,which might serve as a potential model for HIV-1 reservoir research.
【分 类】【农业科学】 > 畜牧、动物医学、狩猎、蚕、蜂 > 动物医学(兽医学) > 兽医基础科学 > 家畜免疫学
【关键词】 HIV-1 病毒库 感染 外周血单个核细胞 猕猴 体内 北方
【出 处】 《科学通报:英文版》2017年 第19期 1315-1324页 共10页
【收 录】 中文科技期刊数据库