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Easily fabricated and recyclable Pd&Cu@Al catalyst for gram-scale phosphine-ffee Heck reactions with high TON

《科学通报:英文版》2017年 第19期 | Dongliang Zhang Zheng Wei Lei Yu   Institute of Pesticide School of Horticulture and Plant Protection Yangzhou University Yangzhou 225009 China School of Chemistry and Chemical Engineering Yangzhou University Yangzhou 225002 China
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摘 要:A unique Pd&Cu@Al catalyst was easily fabricated just by immersing commercial aluminum foil in a mixed xylene solution of PdCl_2 and CuCl_2. The catalyst fabrication process led to aluminum oxide coatings in situ, which supported the metal nanoparticles and enhanced their catalytic activities for the phosphine-free Heck reaction of aryl halides and styrenes with high turnover number(TON) up to 3.9×10~5. The reaction can be scaled up to at least 100 mmol and has been applied in modification of drug Lapatinib's intermediate with low metal residue. This novel catalyst is of good application potential in industrial production because it was extremely easy to be recycled, in regardless of the generation of the insoluble impurities or tars during the reaction processes.
【分 类】【数理科学和化学】 > 化学 > 有机化学 > 有机化学一般性问题 > 有机合成化学 > 不对称有机合成
【关键词】 Heck反应 新型催化剂 铝箔 金属纳米粒子 回收 制造
【出 处】 《科学通报:英文版》2017年 第19期 1325-1330页 共6页
【收 录】 中文科技期刊数据库