学术
摘 要:
[目的]探讨医院常见病原菌对环丙沙星的耐药性变迁，为临床合理用药提供参考依据。[方法]用常规鉴定方法分离鉴定病原菌，用K—B法作体外耐药监测。[结果]从2001～2006年6年临床常见病原菌对环丙沙星耐药率呈上升趋势，总耐药率从2001年的43．1％上升到2006年的67．6％；耐药率居前3位的分别是金黄色葡萄球菌、大肠埃希菌和凝固酶阴性葡萄球菌，其中金黄色葡萄球菌和大肠埃希菌的耐药率增长更为明显，分别达84％和77．6％；而分离率与金黄色葡萄球菌和凝固酶阴性葡萄球菌接近的铜绿假单胞菌和肺炎克雷伯菌耐药率仅为50．2％和36％，耐药率的增长存在明显差异。[结论]临床常见病原菌对环丙沙星的耐药性增长趋势不但与临床广泛应用喹诺酮类药物有关，而且与经验性应用喹诺酮类药物治疗不同部位感染也有相当密切的关系。必须在药敏结果的指导下合理使用以环丙沙星为代表的氟喹诺酮药物，控制细菌的耐药性增长。[著者文摘]
文章出处:
《中国医学检验杂志》-2007年8卷5期 -336-337页
栏目信息:
分 类 号:
文献标识码:
B
文章编号:
1606-8025（2007）05-336-02
相关文章:
RECENT RESISTANCE STATUS TREND OF COMMON BACTERIA TO CIPROFLOXACIN IN HOSPITAL
Zhou Xiaoming, Yan Zihe. （Department of Laboratory Tests, The Second People＇s Hospital of Wuxi, Wuxi 214002, China）
Abstract:
[ Objective] To investigate drug resistance status of common bacteria to ciprofloxacin in hospital for reasonable use of anti- biotics. [ Methods] After genus identification, drug resistance profile was analyzed by K - B method. [ Results] The resistant rate of common bacteria to ciprofloxacin ascended yearly from 43.1% （2001） to 67.6% （2006）, which predominated with S. aureus, Escherichia coli and coagulase negative Staphylococcus, respectively. The tendency of resistance showed that there was a sharp rise in S. aureus and Escherichia coli. The resistance of these two bacteria was relatively high of 84% and 77.6% , rsspectively. However, the resistant rate of Pseudornortas aeruginosa and Klebsiella pneurnoniue which had the same seperation rate were only 50.2% and 36% , respectively. [ Conclusion] The rising tendency of resistance is not only correlated with the extensive using of quinolones but also to the experience of using quinolones in different infected organs. Rational use of fluoroquinolones should be done by obeying the results of laboratory antibiotivs suceptibility test to control the increasing trend of resistance.[著者文摘]
Key words:
Ciprofloxacin; Drug resistance; Bacteria
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