学术
摘 要:
猪肠毒素大肠杆菌F4（ZTECF4）是引起1～2周龄仔猪黄、白痢最普遍、危害最大的大肠杆菌。ETECF4能否致病，决定于猪的小肠上皮细胞有无ETECF4受体。本文综述了ETECF4的黏附模式，F4特异受体在猪小肠中的分布，受体的生化特性，受体编码基因的定位、克隆现状及存在的问题，并对今后F4受体的研究方向及应用前景进行了展望。[著者文摘]
文章出处:
《中国畜牧杂志》-2007年43卷19期 -46-49页
栏目信息:
分 类 号:
文献标识码:
A
文章编号:
0258-7033（2007）19-0046-04
Advances in Enterotoxigenic Escherichia coli F4 Receptors in Piglets
XU Ru-hai, HU Jin-ping, WENG Jing-qiang, CHU Xiao-hong （Institute of Animal Husbandry and Veterinary Science, Zhejiang Academy of Agricultural Sciences, Zhejiang Hangzhou 310021, China）
Abstract:
Strains of enterotoxigenic Escherichia coli that express F4 fimbriae （ETEC F4） are an major cause of diarrhea and mortality in newborn and weaned piglets. The F4 fimbriae mediate adhesion of bacteria to receptors on porcine intestinal epithelial cells, which is the initial step in the establishment of enteric infection.In this paper, the adhesion patterns of ETEC F4 fimbriae, the detection and distribution of F4-specific receptors were reviewed, the biochemical properties of F4-specific receptors, the mapping and cloning of the recptor locus were also summarized. Future perspective on F4-specific receptors research and application were also discussed in this paper.[著者文摘]
Key words:
ETEC F4 receptors; a review; piglets
基金资助:
浙江省农业科学院引导项目（2005R22A70D01）
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