学术
摘 要:
microRNAs（miRNAs）是人类新发现的一类非编码小分子RNA，广泛分布于真核细胞内。miRNAs通过与靶基因互补位点配对结合，在转录后水平负性调控靶基因的表达，参与生长发育、细胞增殖、细胞凋亡、细胞分化等生命过程。据推测，大约1％的人类已知基因编码miRNAs，而miRNAs可调控人类基因组中10％-30％的基因。本文就如何识别miRNAs及其靶基因作一简要介绍。[著者文摘]
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文章出处:
《基础医学与临床》-2007年27卷9期 -1063-1065页
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文献标识码:
A
文章编号:
1001-6325（2007）09-1063-03
Recognition of microRNAs and its-targeting genes
SONG Bao, SONG Xian-rang , LIU Jie, WEI Ling （ Cancer Research Center, Shandong Tumor Hospital and Institute, Jinan 250117, China）
Abstract:
karyotes and microRNAs （miRNAs） are a recently discovered family of small non-coding RNAs, which exist in euregulate gene expression post-transcriptionally by binding to complementary sites MiRNAs play important roles in regulation of cell proliferation, development, apoptosis and cell on target mRNAs. differentiation. It＇ s predicted that about 1% human known genes encode microRNAs and microRNAs may regulate 10 - 30% of the genes in the human genome. The paper focus on the knowledge about how to recognize miRNAs and identify their target mRNAs.[著者文摘]
Key words:
microRNAs（miRNAs） ; non-coding RNA; target mRNA
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