学术
摘 要:
内皮祖细胞来源于骨髓，可分化为成熟有功能的内皮细胞。大量试验证实冠心病和心力衰竭患者内皮祖细胞数量减低，外周循环内皮祖细胞功能受损，许多因素可影响内皮祖细胞的数量及功能。因此，药物动员内皮祖细胞或使其功能正常化有望改善心血管病患者的预后。现总结近来关于影响内皮祖细胞因素的研究，有助于探索未来治疗的新领域。[著者文摘]
文章出处:
《心血管病学进展》-2008年29卷1期 -53-56页
栏目信息:
分 类 号:
文献标识码:
A
文章编号:
1004-3934（2008）01-0053-04
Endothelial Progenitor Cells - Potential Targets of Drug Therapy
NIE Ying, GAO Wei （ Department of Cardiology, The Third Hospital of Peking University, Beijing 100083, China）
Abstract:
Endothelial progenitor cells （ EPC ） are bone marrow derived cells with the potential to differentiate into mature thnctional endothelial cells. Studies have shown that patients with coronary heart disease or heart failure may suffer from decreased amounts and impaired thnetion of peripheral circulating EPC. Drug induced mobilization of EPC and normalization of EPC function may therefore improve the prognosis of certain cardiovascular diseases. This article reviews studies of the factors influencing EPC, and suggests roles it might play in invesgating potential drug targets.[著者文摘]
Key words:
endothelial progenitor cells ; myocardial infarction ; statins ; erythropoietin ; diabetes
基金资助:
“十五”国家科技攻关计划（编号：2004BA714805-01）
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