学术
纳米羟基磷灰石复合胶原/聚乳酸材料复合兔骨髓基质细胞异位成骨的实验研究
刘冰[1] 陈鹏[2] 毛天球[3] 岳进[3]
[1]空军总医院口腔科,北京100036 [2]解放军总医院口腔科,北京100036 [3]第四军医大学口腔医院口腔颌面外科,北京100036
摘 要:
目的：观察nHAC/PLA复合兔BMSCs的异位成骨能力.方法：通过负压吸附使BMSCs与nHAC/PLA材料复合,将nHAC/PLA＋自体BMSCs、自体BMSCs、nHAC/PLA材料分别植入新西兰兔背部肌袋内,术后4、8周通过大体、组织学观察来研究其异位成骨能力.结果：自体BMSCs组与nHAC/PLA材料组在新西兰兔背部肌袋内均无骨质形成,nHAC/PLA＋自体BMSCs组8周时有大量较成熟的骨质形成,同时材料本身部分吸收.结论：通过负压吸附的方法制备出的nHAC/PLA＋自体BMSCs具有良好的异位成骨能力.[著者文摘]
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文章出处:
《口腔医学研究》-2007年23卷3期 -264-266页
栏目信息:
分 类 号:
文献标识码:
A
文章编号:
1671-7651（2007）03-0264-03
Ectopic bone Formation of Nano - hydroxyapatite/collagen/PLA Material Compound with Rabbit BMSCs.
LIU Bing, CHEN Peng, MAO Tianqiu （ Department of Stomatology, General Air Force Hospital of PLA, Beijing 100036）
Abstract:
Objective： To observe the ability of ectopic bone formation of nHAC/PLA compound with rabbit BMSCs. Methods ： The combination of BMSCs and nHAC/PLA in vitro was made through negative pressure adsorbing, nHAC/PLA ＋ autoallergic BMSCs and autoallergic BMSCs, nHAC/PLA material were implanted into musclar pouch of New - Zealand rabbit back, respectively. After four weeks and eight weeks, the ability of ectopic bone formation was tested through gross histology observation. Results： Neither autoallergic BMSCs nor nHAC/PLA material was sclerotized in the musclar pouch of New - Zealand rabbit back. The nHAC/PLA ＋ autoallergic BMSCs was maturely sclerotized in large amount after 8 weeks. The material was partly absorbed. Conclusion： The nHAC/PLA ＋ autoallergic BMSCs produced by negative pressure adsorbing has a good ability of ectopic bone formation.[著者文摘]
Key words:
Nano- hydroxyapatite/collagen/PLA material （nHAC/PLA） Bone marrow stromal cells（BMSCs） Ectopic bone formation Tissue engineering
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