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Biomarkers for diet and cancer prevention research： potentials and challenges
Cindy D DAVIS John A MILNER
Nutritional Science Research Group, National Cancer Institute, Rockville, MD 20892, USA
文章出处:
《中国药理学报：英文版》-2007年28卷9期 -1262-1273页
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Biomarkers for diet and cancer prevention research： potentials and challenges
Abstract:
As cancer incidence is projected to increase for decades there is a need for effective preventive strategies. Fortunately, evidence continues to mount that altering dietary habits is an effective and cost-efficient approach for reducing cancer risk and for modifying the biological behavior of tumors. Predictive, validated and sensitive biomarkers, including those that reliably evaluate ＂intake＂ or exposure to a specific food or bioactive component, that assess one or more specific biological ＂effects＂ that are linked to cancer, and that effectively predict individual ＂susceptibility＂ as a function of nutrient-nutrient interactions and genetics, are fundamental to evaluating who will benefit most from dietary interventions. These biomarkers must be readily accessible, easily and reliably assayed, and predictive of a key process（es） involved in cancer. The response to a food is determined not only by the effective concentration of the bioactive food component（s） reaching the target tissue, but also by the amount of the target requiring modification. Thus, this threshold response to foods and their components will vary from individual to individual. The key to understanding a personalized response is a greater knowledge of nutrigenomics, proteomics and metabolomics.[著者文摘]
Key words:
exposure biomarker; effect biomarker;susceptibility biomarker; nutrigenomics
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