学术
Targeting multiple signal pathways by chemopreventive agents for cancer prevention and therapy
Fazlul H SARKAR Yi-wei LI
Department of Pathology Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
文章出处:
《中国药理学报：英文版》-2007年28卷9期 -1305-1315页
分 类 号:
Targeting multiple signal pathways by chemopreventive agents for cancer prevention and therapy
Abstract:
In recent years, growing interest has been focused on the field of cancer prevention. Cancer prevention by chemopreventive agents offers significant promise for reducing the incidence and mortality of cancer. Chemopreventive agents may exert their effects either by blocking or metabolizing carcinogens or by inhibiting tumor cell growth. Another important benefit of chemopreventive agents is their nontoxic nature. Therefore, chemopreventive agents have recently been used for cancer treatment in combination with chemotherapeutics or radiotherapy, uncovering a novel strategy for cancer therapy. This strategy opens a new avenue from cancer prevention to cancer treatment. In vitro and in vivo studies have demonstrated that chemopreventive agents could enhance the antitumor activity of chemotherapeutics, improving the treatment outcome. Growing evidence has shown that chemopreventive agents potentiate the efficacy of chemotherapy and radiotherapy through the regulation of multiple signaling pathways, including Akt, NF-κB, c-Myc, cyclooxygenase-2, apoptosis, and others, suggesting a multitargeted nature of chemopreventive agents. However, further in-depth mechanistic studies, in vivo animal experiments, and clinical trials are needed to investigate the effects of chemopreventive agents in combination treatment of cancer with conventional cancer therapies. More potent natural and synthetic chemopreventive agents are also needed to improve the efficacy of mechanism-based and targeted therapeutic strategies against cancer, which are likely to make a significant impact on saving lives. Here, we have briefly reviewed the role of chemopreventive agents in cancer prevention, but most importantly, we have reviewed how they could be useful for cancer therapy in combination with conventional therapies.[著者文摘]
Key words:
chemoprevention; chemotherapy; Akt;NF-κB; c-Myc; cyclooxygenase-2
基金资助:
This work was funded by grants from the National Cancer Institute （No 5R01 CA083695, 5R01CA101870, and 5R01CA108535 awarded to FHS）, a subcontract award to FHS from the University of Texas MD Anderson Cancer Center through a Specialized Program of Research Excellence （SP0RE） grant （No 5P20-CA 101936） on pancreatic cancer awarded to James Abbruzzese, and a grant from the Department of Defense （D0D Prostate Cancer Research Program DAMD17-03-1- 0042 awarded to FHS）.
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