学术
丝状真菌基因敲除技术研究进展
许杨[1,2] 涂追[1,2]
[1]南昌大学中德联合研究院,江西南昌330047 [2]南昌大学食品科学教育部重点实验室,江西南昌330047
摘 要:
丝状真菌在自然界分布广泛，与人类的生产、生活密切相关。近年来，对于其基因功能的研究取得了较大的进展，一系列转化和基因操作技术已在不同的丝状真菌中得到运用。许多对于工业、农业和医药卫生具有重要意义的丝状真菌已经完成或正在进行全基因组序列测定。作者简述了丝状真菌基因敲除的历史，重点介绍了近年来基因敲除技术在丝状真菌研究中的进展，并对冀在丝状真菌基因功能研究、工业菌株改良等方面进行了展望。[著者文摘]
文章出处:
《食品与生物技术学报》-2007年26卷1期 -120-126页
栏目信息:
分 类 号:
文献标识码:
A
文章编号:
1673-1689（2007）01-0120-07
Application and Progress of Filamentous Fungi Gene Targeting
XU Yang, TU Zhui （1. Sino-Germany Joint Research Institute, National Key Laboratory of Food Science, Nanchang University, Nanchang 330047, China; 2. Ministry of Education, Nanchang 330047, China）
Abstract:
Gene targeting technology which based on homologous recombination is an important strategy in functional genomics, and it has been wildly used in the genome specific manipulation, especially applied in the genetic trait modification of animal. However, the efficiency of gene targeting in filamentous fungi is usually low. Recent years, tremendous efforts have been made to improve the efficiency. This paper introduced the history of gene targeting in filamentous fungi. The latest application and research progress have also been reviewed.[著者文摘]
Key words:
filamentous fungi; gene targeting; gene replacement; homologous recombination
基金资助:
国家自然科学基金项目（30460006）和长江学者和创新团队发展计划项目（IRT0540）.
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