结扎兔基底动脉后对呼吸和血压的影响
张翠英[1] 卢彦珍[2] 范毅敏[3] 王黎敏[3] 尚改萍[1]
[1]长治医学院生理学教研室,046000 [2]长治医学院病理生理学教研室,046000 [3]长治医学院机能综合实验室,046000
摘 要:
目的:观察结扎兔基底动脉后呼吸和血压的变化,为进一步探讨基底动脉供血障碍影响呼吸和循环等功能活动的机制和防治措施提供依据。方法:以兔为实验对象,采用单点结扎的方法在基底动脉起始部结扎,分别用膈肌放电和股动脉血压为指标,动态观察呼吸和血压的变化。结果:结扎基底动脉2h后,兔呼吸活动发生明显改变,表现为吸气时程(TI)缩短(P〈0.05),呼气时程(TE)缩短(P〈0.01),呼吸频率(RF)加快(P〈0.05),与对照组相比均有显著差异;平均动脉压(MBP)与对照组相比,无显著差别(P〉0.05)。结论:单点结扎基底动脉起始部可以引起延髓缺血性损伤,并可导致呼吸功能发生改变。[著者文摘]
文章出处:
《长治医学院学报》-2007年21卷5期 -321-323页
栏目信息:
分 类 号:
文献标识码:
A
文章编号:
1006-(2007)05-0321-03
Effects of Ligating Basilar Artery on Respiration and Blood Pressure in Rabbit
Zhang Cuiying, Lu Yanzhen, Fan Yimin, et al.( Department of Physiology, Changzhi Medical College)
Abstract:
Objective: To invest!gate the effects of ligating basilar artery trunk on respiration and blood pressure, and to give evidences on how medullary ischemia affected respiration and circulation an on how to protect against it. Methods: In the rabbits of the experimental group, the beginings d give some advices of the basilar artery trunk were ligated and the electromyogram of the diaphragm and the blood pressure of the femoral artry were investigated. Results: Both the inspiratory duration (TI) ( P 〈 0.05) and expiratory duration (TE) ( P 〈 0.01 ) were shortened, and respiratory frequency (RF) increased ( P 〈 0.05 ), but mean blood pressure (MBP) was changeless compared with control group( P 〉 0.05). Conclusion:Ligating the basilar artery trunk might induce medullary focal ischemia damage that resulted in the changes in the respiratory function.[著者文摘]
Key words:
Basilar Artery;Medulla;Ischemia;Respiration;Blood pressure;Rabbit
基金资助:
山西省教育厅实验室建设资金资助(2005117)

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