学术
猪胰岛素样生长因子Ⅰ基因表达与调控的研究进展
肖书奇[1] 李爽[1] 张嘉保[1] 任文陟[1] 刘保国[2] 赵志辉[1] 赵中利[1] 张树敏[3]
[1]吉林大学农学部实验动物中心,吉林长春130062 [2]河南科技学院动物科学学院,河南新乡453003 [3]吉林省农业科学院畜牧分院,吉林公主岭136100
摘 要:
胰岛素样生长因子-Ⅰ（Insulin—like growth factor—Ⅰ，IGF-Ⅰ）是机体生长、发育和代谢的一个重要调控因子，同时也是生长激素（growth hormone，GH）启动生长活性的主要介导者。血液中的IGF-Ⅰ主要来源于肝脏，以内分泌的形式作用于其他组织；许多肝外组织也能合成IGF-Ⅰ，其主要以自分泌或旁分泌的形式发挥作用。多种因素调控其表达。本文就猪IGF—Ⅰ的表达与调控方面的最新研究进展进行一综述。[著者文摘]
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文章出处:
《家畜生态学报》-2007年28卷4期 -90-92页
栏目信息:
分 类 号:
文献标识码:
A
文章编号:
1004-5228（2007）04-0090-03
Expression and Regulation of the Pig Insulin-like Growth Factor-IGene
XIAO Shu-qi, LI Shuang, ZHANG Jia-bao , REN Wen-zhi, LIU Bao-guo, ZHAO Zhi-hui, ZHAO Zhong-Li, ZHANG Shu-min （1. Laboratary Animal Center,Agronomy Department , Jilin University,Changchun,Jilin 130062; 2. College of Animal Science , Henan Institute of Scence and Technology, Xinxiang, Henan 453003 ; 3. Branch of Animal Scievice Jilin Academy of Agriculture Sciences,Gongzhuling,Jilin 136100 ）
Abstract:
Insulin-like growth factor-Ⅰ（IGF-Ⅰ） is an important regulator of growth, development, metatabolism, and is the primary mediator of the growth-promoting activity of growth hormone（GH） in mammals. The primary source of IGF-Ⅰ is the liver, from which IGF-Ⅰ is released into the blood and acts in an endocrine mode on other tissues. IGF-Ⅰ is also synthesized in many extrhepatic tissues, where it functions in an autocrine or paracrine manner. IGF-Ⅰ gene expression is controlled by many factors. This article reviewed the latest research progress of expression and regulation of the pig IGF-Ⅰ gene.[著者文摘]
Key words:
pig; insulin-like growth factor-Ⅰ; expression; regulation
基金资助:
国家振兴东北老工业基地科技攻关项目（2004BA907A22）资助.
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