学术
川芎嗪治疗实验性肾损伤机理的研究
谭洪华[1] 李霞[2] 薄爱华[3] 邢立强[3] 薛贵平[4]
[1]河北北方学院教务处,河北张家口075000 [2]张家口市社会福利总院,河北张家口075000 [3]河北北方学院实验中心,河北张家口075000 [4]河北北方学院药理教研室,河北张家口075000
摘 要:
目的：观察川芎嗪治疗实验性免疫性肾损伤作用和机理,为中药治疗肾小球肾炎开辟新途径。方法：猪血清腹腔注射8周,复制大鼠实验性肾损伤模型,川芎嗪治疗4周后处死动物,检测尿蛋白、血清BUN和Scr含量,取肾组织制作光、电镜标本检查。结果：川芎嗪大、小剂量组尿蛋白、血清BUN和Scr含量较模型组明显降低（P〈0.01）,肾小球的病理形态学改变较模型组轻。结论：川芎嗪具有治疗大鼠实验性免疫性肾损伤的作用。[著者文摘]
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A
文章编号:
1673-1484（2007）04-0007-03
Study on the Treating Mechanism of Tetramethylpyrazine on Experimental Immune Renal Injury
TAN Hong-hua, LI Xia,BO Ai-hua,et al （Hebei North University, Zhangjiakou, 075000, Hebei, China）
Abstract:
Objective： To further investigate possible ways for treating immune renal injury by traditional Chinese medicine Tetramethylpyrazine（T）. Methods： Rats were administrated intra-abdominally fresh swine serum to induce immune renal ingury model and then were treated with Tetramethylpyrazine respectively. Urine protein （UP）, serum BUN and Scr were measured and the kidney specimens were taken from abdomen and prepared for light and electron microscopic examiniation. Results： The above UP and serum parameters in T group did have significant differences with that of model control group（P〈0.01）. Light and electron microscopic examiniation showed that, compared with model control group, no obvious pathological changes were found in the kidney of T group. Conclusion： Tetramethylprazine has the effect of anti immune renal injury in rats.[著者文摘]
Key words:
Tetramethylprazine; Renal injury; Pharmacology; Disease model; Rat
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