学术
摘 要:
目的 分析医院与社区获得性感染的金黄色葡萄球菌（SAU）耐药现状，给临床合理用药提供参考。方法 收集2004—2006年临床分离的金黄色葡萄球菌，培养鉴定，采用纸片扩散法（K—B法）或微量稀释法（MIC）测定16种抗菌药物的敏感情况，用WHONET5软件进行分析。结果 440株金黄色葡萄球菌，其中耐甲氧西林金黄色葡萄球菌（MRSA）为260株，占59．1％；甲氧西林敏感金黄色葡萄球菌（MSSA）为180株，占40．9％；SAU对16种抗菌药物的耐药率最高的是青霉素G为85．5％、万古霉素耐药率为0。结论 MSSA对大部分抗菌药物仍保持较好的敏感性，而MRSA表现为多重耐药性，但万古霉素例外，所以对耐万古霉素金黄色葡萄球菌（VISA及VRSA）的连续监测、了解葡萄球菌属的耐药机制具有重要的临床意义。[著者文摘]
文章出处:
《中华医院感染学杂志》-2007年17卷10期 -1292-1293页
栏目信息:
分 类 号:
文献标识码:
A
文章编号:
1005-4529（2007）10-1292-02
Drug Resistance of Staphylococcus aureus ： Current Situation and Clinically Therapeutic Countermeasures
JIANG Jing-hua, CHEN Wen-guang, ZHANG Ze-bao, TAO Ying, GUO Ya-chun, WANG Zong-xin （Shaoxing People＇s Hospital, Shaoxing, Zhejiang 312000, China）
Abstract:
OBJECTIVE To analyze the current situation of the hospital, and the community-acquired infections due to Staphylococcus aureus （SAU） and provide the reference for clinical reasonable use of drugs. METHODS The clinically isolated S. aureus strains during 2004-2006 were collected, cultured and identified. Their susceptibilily to 16 kinds of antibacterials was detected by K-B or MIC and WHONET5 software was used to analyze the result. RESULTS From 440 S. aureus strains, the meticillin-resisstant S. aureus （MRSA） was 260 accounting for 59. 1% ;the meticillin-sensitive S. aureus （MSSA） was 180 accounting for 40. 9%. The resistant rate of SAU to penicillin G was the highest（85.5%）, that to vancomscin was 0. CONCLUSIONS MSSA still keeps fairly good sensibility to most antibacterial medicine, but MRSA shows the multidrug resistance, except to vancomycin. For this studying the resistance mechcnism of Staphylococcus and continuously detecting the emergence of vancomycinintermediat and vancomycin-resistante S. aureus have a significant clinicil importance.[著者文摘]
Key words:
Staphylococcus aureus ; Antibacterials; Vancomycin; Drug resistance surveillance; Treatment
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