学术
摘 要:
目的：观察霉酚酸酯（mycophenolate mofetil,MMF）和冬虫夏草人工制剂（金水宝）联合治疗HBV-DNA阳性肾小球疾病的有效性,安全性。方法：对10例HBV-DNA阳性的肾小球疾病患者用MMF和金水宝治疗。在治疗前及治疗6个月后测定肝肾功能、血白细胞、血红蛋白、24 h尿蛋白定量、HBV-DNA滴度及肾组织活检。结果：治疗后尿蛋白,血肌酐,HBV-DNA均明显下降,差异有显著性（P〈0.05）,而血白细胞、血红蛋白、谷丙转氨酶,治疗前后无明显变化（P〉0.05）。结论：霉酚酸酯和金水宝联合治疗HBV-DNA阳性的肾小球疾病为一种较安全有效的方法,但尚需扩大临床研究。[著者文摘]
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文章出处:
《实用临床医学（江西）》-2007年8卷9期 -22-24页
栏目信息:
分 类 号:
文献标识码:
A
文章编号:
1009-8194（2007）09-0022-03
The Therapeutic Efficacy of Mycophenolate Mofetil Combined with Jinshuibao in the Renal Glomerular Disease Patients with Positive HBV-DNA
WANG Yu, CHEN Qin-kai, ZHOU Jing, LI Qiu-yue, LUO Lai-min, YANG Liu （Department of Nephrology , the First Affiliated Hospital of Nanchang University, Nanchang 330006, China）
Abstract:
Objective：To observe the therapeutic efficacy and safety of MMF combined with Jinshuibao in renal glomerular disease patients with HBV-DNA positive.Methods：Ten patients with renal glomerular disease received MMF 0.5 g twice a day for three months,then 0.25 g twice a day for three months more,simultaneously,received JinshuiIbao 1.8 g three times a day for six months by oral administration.Before and after the treatment,the alanine aminotransferase（ALT）,serum creatinine（Scr）,WBC,Hb,HBV-DNA,24 h urinary protein and nephridial tissue pathology were detected.Results：Six months later,24 h urinary albumin,Scr HBV-DNA decreased significantly（P〈0.05）,but WBC,Hb,ALT had little change（P〉0.05）.Conclusion：The therapeutic alliance of MMF combined with JinshuiIbao may be a efficient and safe way to renal glomerular disease patients with positive HBV-DNA.[著者文摘]
Key words:
HBV-DNA cordyceps sinensis;renal glomerular disease;Jinshuibao
基金资助:
江西省卫生厅资助项目（0303009）
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