学术
摘 要:
背景：对青少年短期的研究显示菊粉类型的果聚糖对钙吸收有促进。尽管结果不总是一致，也没有进行长期的研究。 目标：评价特种菊粉类果聚糖对钙吸收和骨矿物质沉积的短、长期影响。设计：任选处于青春发育期青少年数名接受每天8克某种菊粉类果聚糖（SYNERGYl）或麦芽糊精进行为期一年的控制性试验。在试验之前和一年以后测量骨矿物质含量和骨矿物质密度。在试验初期，一周和一年后分别测定钙吸收。测定维生素DFokl受体基因的多态性。 结果：SYNERGYl组比控制组在6周后有显著的钙吸收（7．7±1．7％，P〈0．001）和一年后（5．7）±2．8％，P=0．048）。论述Fokl基因类型的干扰，如基因类型对SYNERGYl有了最初的反应。相对于试验组，SYNERGYl对骨钙有较大的日平均沉积率。（30土15mg／d，P=0．04）和骨矿物质密度（总和Z—Score）变化（Z—score变化=0．18±0．08，P=0．02）。 结论：每天服用强化低聚果糖的菊粉（SYN—ERGYl）在青春发育期显著增进短、长期钙吸收，并促进骨钙化。膳食因素对钙吸收的影响可通过基因因素来构造模型。基因因素指民族指有的和特定的维生素D受体基因的多态性。[著者文摘]
文章出处:
《中国食品添加剂》-2006年C00期 -76-77页
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Oligofructose- enriched inulin enhances calcium absorption and bone mineral accretion in adolescents
Ir. Msc., Koen Van Praet （ORAFTI Active Food Ingredients）
Abstract:
BACKGROUND： short-term studies in adolescents have generally shown an enhancement of calcium ab- sorption by inulin-type fructans although results have not always been consistent and there are no long-term studies. OBJECTIVE： Assess the effects of short and long-term supplementation with a specific inulin type fructan on calcium absorption and bone mineral accretion. DESIGN： Pubertal adolescents were randomized to receive 8 g/d of a specific inulin-type fructan （ SYNERGY1 ） or maltodextrin control （CONTROL） for one-yr. Bone mineral content and bone mineral density were determined prior to randomization and after one yr. Calcium absorption was measured at baseline, 6 weeks, and one yr after one yr after randomization. Polymorphisms of the Fokl vitarmin D receptor gene were determined. RESULTS： SYNERGY1 subjects had significantly greater calcium absorption than CONTROL at 6 wks （7.7 ±1.7%, p 〈0.001） and one year （5.7 ± 2.8%, p = 0. 048）. An interaction with Forl genotype was present such that if genotype subjects had the least initial response to SYNERGY1. SYNER- GY1 had a greater average daily skeletal calcium accretion （30 ±15mg/d, p =0. 04） and bone mineral density （ total and Z - score ） change （ Z - score difference = 0. 18 ± 0. 08, p = 0. 02 ） than CONTROL. CONCLUSION： Daily consumption of oligofructose - enriched inulin （ SYNERGY1 ） significantly increases short and long-term calcium absorption and enhances bone mineralization during pubertal growth. Effects of dietary factors on calcium absorption may be modulated by genetic fators including ethnicity and specific vitamin D receptor gene polymorphisms[著者文摘]
Key words:
calcium absorption, vitamin D receptor, stable isotopes, inulin, prebiotics, pubertalgrowth, bioavailability.
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