学术
摘 要:
1-（2，3-二氯苯基）哌嗪盐酸盐是重要的医药中间体。以二乙醇胺为起始原料，经氯代反应制得卢属。二氯代二乙基胺盐酸盐，然后在水溶液中不使用催化剂条件下与2，3-二氯苯胺经环合反应合成目标化合物1-（2，3-二氯苯基）哌嗪盐酸盐。产物结构经红外光谱、核磁共振氢谱分析验证与目标化合物的结构一致。该方法经济环保。简单易操作。[著者文摘]
关 键 词:
文章出处:
《精细化工中间体》-2008年38卷1期 -18-21页
栏目信息:
分 类 号:
文献标识码:
A
文章编号:
1009-9212（2008）01-0018-04
Novel Synthesis of 1-（2,3-Dichlorophenyl） Piperazine Hydrochloride
ZHU Xiao-bin, XU Chong-fu, CHEN Miao（College of Chemistry and Chemical Engineering, Jiangsu Province Key Lab of Petrochemical Engineering, Jiangsu Polytechnic University, Changzhou 213164, China）
Abstract:
1-（2,3-Dichlorophenyl）piperazine hydrochloride is an important pharmaceutical intermediate. The starting material diethanolamine was halogenated to giveβ,β＇-dihalogenated diethyiammonium hydrochloride, and then reacted with 2,3-dichloroaniline in aqueous solution without any catalyst to afford the target compound piperazine hydrochloride. The product was characterized by ^1H NMR and IR spectroscopy whic proposed structures. 1-（2,3--dichlorophenyl） h was consistent with the[著者文摘]
Key words:
1-（2,3-dichlorophenyl）piperazine hydrochloride; cyclo-condensation; diethanolamine
基金资助:
江苏工业学院科技基金（ZMF05020022）.
更多>>免费文章
cqvip.com