学术
重氮乙酸乙酯的合成与含量分析
王红利[1,2] 刘改玲[1,2] 李争宁[1,2] 陈惠麟[3]
[1]大连大学环境与化工学院,辽宁大连116622 [2]辽宁省生物有机化学重点实验室,辽宁大连116622 [3]中国科学院大连化学物理研究所,辽宁大连116023
国际标准刊号：ISSN 1009-9212
国内统一刊号：CN 43-1354
摘 要:
对亚硝酸钠与甘氨酸乙酯盐酸盐合成重氮乙酸乙酯的过程进行了改进，在滴加亚硝酸钠前给体系中加入适量强酸可以促进反应平稳进行，收率达95、8％，建立了用紫外光谱法测定溶液中重氮乙酸乙酯的方法。该合成方法经工业实验．适于大规模生产。[著者文摘]
文章出处:
《精细化工中间体》-2008年38卷1期,46 -40-43,46页
Fine Chemical Intermediates
栏目信息:
分 类 号:
文献标识码:
A
文章编号:
1009-9212（2008）01-0040-04
The Synthesis and Analysis of Ethyl Diazoacetate
WANG Hong-li, LIU Gai-ling, LI Zheng-ning, CHEN Hui-lin（1. College of Environmental and Chemical Engineering, Dalian University, Dalian 116622, China; 2. Liaoning Key laboratory of Bioorganic Chemistry, Dalian 116622, China; 3. Dalian Institute of Chemical Physics, The Chinese Academy of Sciences, Dalian 116023, China）
Abstract:
The procedure for the preparation of ethyl diazoacetate via the reaction of sodium nitrate with ethyl glycinate hydrochloride was modified. Strong acid was added to the reaction media prior to the addition of sodium nitrate to promote the reaction proc concentration preparation. eeding steadily, and the yield reached 95.8% under the optimal conditions. A method for determining the of ethyl diazoacetate by UV spectroscopy was developed. The procedure was applicable to large scale[著者文摘]
Key words:
ethyl diazoacetate; synthesis ; analysis ; diazotization
收稿日期: 2007-11-18
更多评论>>文章评论
更多>>免费文章
cqvip.com