学术
真核生物基因组转录诱导融合基因的研究进展
吕聪颖[1] 赵刚彬[1] 吕贯廷[2]
[1]南阳理工学院计算机科学与技术系,南阳473004 [2]中国科学院北京基因组研究所,北京101300
摘 要:
真核生物的基因组由基因和基因间区组成．基因转录时，从转录起始点开始到该基因的转录终止点结束，形成独立的转录单元．然而有少量的文献表明，转录有时会通读基因间区，产生包含上游基因、基因间区和下游基因的融合基因转录本．融合转录本经基因间剪接而成为有功能的成熟转录本．对真核生物转录诱导融合基因的基因间剪接方式、产生机制和意义进行了综述．[著者文摘]
文章出处:
《生物化学与生物物理进展》-2007年34卷12期 -1255-1259页
栏目信息:
分 类 号:
of The Transcription-mediated Fusion Genes in Eukaryotic Genomes
LU Cong-Ying, Zhao Gang-Bin Guan-Ting（ College of Computer Science and Technology, Nanyang Institute of Technology, Nanyang 473004,China; 2） Beijing Institute of Genomies, The Chinese Academy of Sciences, Beijing 101300, China）
Abstract:
Eukaryotic genomes are composed of individual genes and their intergenic regions. Traditionally, it has been held that the transcription of a gene always begins from the transcription start site and ends at the termination site, the gene is referred as an individual transcription unit. However, some sporadic studies indicate that transcription can sometimes read-through the intergenic region and generates a large fusion transcript which contains the upstream gene, intergenic region and the downstream adjacent gene. The fusion transcript becomes a mature functional transcript after intergenic splicing. The patterns of intergenic splicing, possible generation mechanism and its significance are summarized.[著者文摘]
Key words:
intergenic region, transcription, fusion transcript
基金资助:
国家自然科学基金重点项目（60433020）和教育部重点项目（02090）.
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