学术
一个基于熵的对疾病基因精细定位的指数
李玉梅[1,3] 向阳[2,3] 邓红文[4,5] 孙振球[1]
[1]中南大学公共卫生学院,长沙410078 [2]中南大学数学学院,长沙410081 [3]怀化学院数学系,怀化418008 [4]湖南师大分子与统计遗传实验室,长沙410081 [5]Del：IartmentsofOrthopedicSurgeryandBasicMedicalScience,SchoolofMedicine,UniversityofMissouri-KansasCity,Kansas MO 64108,USA
摘 要:
针对人类疾病基因的精细定位,本文利用稠密的标记位点,通过比较标记的熵和条件熵,给出了一个基于熵的指数。该指数可以度量标记基因和性状位点间连锁不平衡（LD）程度。该指数的特性是它不依赖于标记基因的频率。同时它对应疾病易感位点（DSL）精细定位的哈迪-温伯格不平衡（HWD）指数。通过计算机模拟,文章调查了不同遗传参数下该指数的性质。模拟结果表明该指数用作疾病易感位点精细定位是有效的。[著者文摘]
文章出处:
《遗传学报》-2007年34卷7期 -661-668页
栏目信息:
分 类 号:
An Entropy-based Index for Fine-scale Mapping of Disease Genes
Yumei Li, Yang Xiang, Hongwen Deng, Zhenqiu Sun（1. School of Public Health, Central South University, Changsha 410078, China; 2, College of Mathematics, Central South University, Changsha 410081, China; 3. Mathematics Department of Huaihua College, Huaihua 418000, China; 4. College of Life Sciences, Hunan Normal University, Changsha 410081, China; 5. Departments of Orthopedic Surgery and Basic Medical Science, School of Medicine, University of Missouri-Kansas Kansas MO 64108, USA）
Abstract:
By comparing the entropy and the conditional entropy in a marker, an entropy-based index has been presented for fine-scale linkage disequilibrium gene mapping using high-density marker maps for human disease genes. The index can quantify the level of linkage disequilibrium （LD） between the marker and the disease susceptibility locus （DSL） of genes. The advantage of using the index is attributed to the fact that it does not depend on marker allele frequencies across loci. Moreover, it is parallel to Hardy-Weinberg disequilibrium （HWD） measure for DSL fine mapping. Through various simulations, the fine mapping perform- ances of the proposed entropy-based index was extensively investigated under various genetic parameters. The results show that the index presented is both robust and powerful for DSL mapping in genes.[著者文摘]
Key words:
entropy; entropy-based index; fine mapping
基金资助:
This work was supported by the Scientific Research Fund of Huaihua University.
更多>>免费文章
cqvip.com