Mission of JADA Foundational Science JADA Foundational Science (JADA FS) is a cross-disciplinary, open access journal publishing original research articles and reviews on a broad range of topics in dental, oral, and craniofacial health. JADA FS provides a forum for researchers in basic and applied sciences to make their work visible to experts in clinical dentistry and medicine. The aim is to highlight foundational science, as well as new and emerging scientific ideas, tools, and techniques, as they are applied to research questions in oral and craniofacial health. Pertinent studies are invited in the areas of biology, chemistry, engineering, materials science, computer science and informatics, advanced imaging and processing, and other technologies. Our goal is to recruit timely and innovative work of high scientific rigor that is applicable to the field of oral and craniofacial health, presented in a way that is engaging and instructive to both research scientists and clinicians. JADA FS employs a double-blind peer review process. The journal adheres to the principles of transparency and best practices as outlined by COPE (https://publicationethics.org/) and ICMJE (http://www.icmje.org/). EDITORIAL POLICY All statements of opinion and of supposed fact are published under the authority of the authors, including editorials and letters. They are not to be accepted as the views of the American Dental Association or its subsidiaries unless such statements have been expressly adopted by the Association. Articles are accepted with the understanding that they have not been published previously and that they are submitted solely to The Journal. Information on any products mentioned may be available from the authors. Neither the American Dental Association nor any of its subsidiaries has any financial interest in any products mentioned in editorial content, and The Journal requires all authors to disclose any financial or other interests they may have in products or services described in their articles. DISCLAIMER Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds or experiments described herein. Because of rapid advances in the medical and oral-health sciences, in particular, independent verification of diagnoses and drug dosages should be made. To the fullest extent of the law, no responsibility is assumed by Elsevier or the American Dental Association for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein. NOTICE No responsibility is assumed by the publisher or the American Dental Association for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions or ideas contained in the material herein. Because of rapid advances in the medical sciences, in particular, independent verification of diagnoses and drug dosages should be made. Although all advertising material is expected to conform to ethical (medical) standards, inclusion in this publication does not constitute a guarantee or endorsement of the quality or value of such product or of the claims made of it by its manufacturer.