This title has ceased (2019)Pathobiology of Aging and Age-related Diseases (PBA) is a new journal on the pathological progression and intervention of aging and age-related disease phenotypes in mammalian species, providing an opportunity to communicate pathology data as a primary scientific focus of aging. Data describing the pathological features of aging and the diseases generally associated with aging have unique challenges. By design, pathology covers a wide range of disciplines, and has an underlying focus of addressing mechanisms using a pathological basis to define the progression of age-associated lesions. These types of data are by nature highly descriptive and informative. The emerging field of aging research has created a need for dissemination of this type of information, especially in mammalian model organisms and humans. PBA is interdisciplinary in nature and covers all aspects of pathology of aging related to disease phenotypes including cancer, cardiovascular disease, neurological disorders, metabolic dysfunction, renal and gastrointestinal disorders, endocrine dysfunction, musculoskeletal conditions and skin disorders. The underlying theme is based on the sound scientific principles of the pathogenesis of aging and age-related diseases as well as intervention data with resolution of pathological endpoints. The pursuit of investigations into the science of aging is designed to understand why cellular processes begin to fail with advancing age, and what molecular events contribute to this failure. Pathology is the study of the events associated with the gross, histological, and cellular conditions considered abnormal. In this regard, the pathobiology of aging and age-related diseases is an entity that fits nicely under the pathology umbrella, with the integration of physiology and anatomy as key components to a comprehensive assessment of abnormal versus normal. We hope to enlighten the scientific community by recognizing outstanding pathology-based scientific contributions in PBA, and allowing scientists to communicate data that might be of less interest in other journals more focused on generic aging or specific scientific disciplines. We will only publish manuscripts that meet the highest standards of science, but the nature of our journal will allow highly detailed and image intensive descriptions of the pathology of aging and disease conditions generally associated with aging. In this regard, technical reports and case studies will be welcome. We are especially interested in developing a focus for advancing the pathological basis of aging in mammalian systems, especially the mouse and humans. The emphasis will be on preclinical studies as well as clinical studies related to strategies developed in animal models and will be image intensive. Papers on the basic biology of aging in invertebrates will not be considered unless comparative mammalian data is also included. Scope