A single-blind peer-review, online-only, and Gold Open Access journal, JAMIA Open provides a global forum for the publication of novel research and insights in the major areas of informatics for biomedicine and health (e.g., translational bioinformatics, clinical research informatics, clinical informatics, public health informatics, and consumer health informatics), as well as related areas such as data science, qualitative research, and implementation science. JAMIA Open articles, which include application notes, database notes, and patient/community perspectives, alongside original research, reflect the broad diversity of the field of informatics community, focusing on the intersection of informatics, health, communication, and technology, and how that intersection can support patient care through research, practice, and education. JAMIA Open authors are encouraged to make data and source code accessible through publicly accessible repositories that can be cited using digital object identifiers. Accepted manuscripts will be required to have a patient/community facing abstract that highlights key findings.