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摘要： 在真实世界中应用银杏叶滴丸治疗冠心病、脑梗死的基础上,对其合并用药信息采用社区发现算法(Louvain算法)进行复杂网络分析,挖掘其合并用药规律。在冠心病的临床用药方面,银杏叶滴丸常合并应用的西药主要有阿司匹林、氯吡格雷、阿托伐他汀、氨氯地平、单硝酸异山梨酯等,合并应用的中药以注射用灯盏花素、注射用丹参多酚酸盐为主;其合并用药组合主要有阿司匹林+单硝酸异山梨酯/阿托伐他汀/氨氯地平/曲美他嗪、氯吡格雷+注射用丹参多酚酸盐/匹伐他汀/氨氯地平/阿托伐他汀、阿托伐他汀+氨氯地平。在脑梗死的联合用药方面,银杏叶滴丸常合并应用的西药主要有阿司匹林、阿托伐他汀、氨氯地平、氯吡格雷、硝苯地平等,合并应用的中药以注射用灯盏花素、疏血通注射液为主;其联合用药组合主要有阿司匹林+氨氯地平/阿托伐他汀/疏血通注射液/硝苯地平、阿托伐他汀+氯吡格雷/氨氯地平、注射用灯盏花素+阿司匹林/奥拉西坦。本研究中的数据来源于真实世界,对临床医生的诊疗具有一定的参考意义。
关键词: 银杏叶滴丸 ；合并用药 ；复杂网络 ；Louvain算法 ；真实世界
被引量
6
摘要： 该研究针对真实世界中醒脑静注射液治疗脑出血的情况,采用Tabu搜索算法进行分析。通过分析筛选出脑出血病因治疗:醒脑静注射液+止血类药物活血化瘀类;脑出血并发脑水肿者:联合甘露醇或甘露醇+七叶皂苷。脑出血急性期伴相关并发症的患者可根据适应症选择:①氨甲环酸+奥拉西坦+哌拉西林钠舒巴坦钠+乳酸钠林格;②氨甲环酸+奥拉西坦+硝苯地平+卡托普利+甲氧氯普胺+西咪替丁;③胰岛素+泮托拉唑+硝普钠。稳定期合并病的联合治疗可根据适应症选择:①单唾酸四己糖神经节苷脂钠+小牛血清去蛋白+硝酸甘油+复合磷酸氢钾;②依达拉奉+神经节苷脂+卡托普利+左氧氟沙星+痰热清注射液+氨茶碱。活血化瘀类用药子群模块的分析提示脑出血治疗中应用活血化瘀类中成药要注意其用药安全性。该文属于真实世界研究,存在数据缺失及混杂因素等问题,归纳的用药方案仅供临床医师参考,在该研究基础上,可进一步开展前瞻性临床疗效和安全性评价。
关键词: 脑出血 ；醒脑静注射液 ；联合用药 ；真实世界研究 ；Tabu搜索算法
被引量
15
【期刊论文】 • 谢静 1王文佳 1侯瑜超 1廖欧萍 1
+6位作者
• 《World Journal of Acupuncture-Moxibustion》 CSCD
中科院4区
JCR:Q3
• 2024年第2期 83 -
88， 共6页
摘要： Crohn's disease(CD) is an inflammatory bowel disease whose pathogenesis remains unclear.In this paper,we reviewed the basic research of acupuncture and moxibustion in treating CD by regulating intestinal intrinsic immunity,and summarized in more detail that acupuncture and moxibustion can regulate the intestinal intrinsic immune system through the intestinal epithelial cell barrier,monocytes/macrophages,natural killer cells(NK cells),dendritic cells(DC),and neutrophils.Specifically,acupuncture and moxibustion can reduce the expression of inflammatory factors in the intestinal mucosa,alleviate intestinal fibrosis to repair the mechanical barrier of the intestinal mucosa,inhibit the expression of molecules of the MAPK,TLR/NF-κB signaling pathway and inflammatory factors,block the NK cell-mediated cytotoxicity pathway,and prevent the overactivation of neutrophils to control inflammatory responses,repairing the damaged intestinal tract and alleviating CD symptoms.This paper illustrated the characteristics of acupuncture and moxibustion for CD,which involves multi targets and pathways,aiming to provide guidance for the clinical application and basic research of acupuncture and moxibustion for CD.It also pointed out the current drawbacks of acupuncture and moxibustion therapy,and finally proposing the shortcomings of the current research,including the insufficient number of studies on acupuncture and moxibustion in the treatment of CD through the modulation of NK cells and neutrophils,the lack of standardization in acupuncture point selection,duration and treatment course,and the geographical limitations of the research locations for acupuncture and moxibustion in treating CD.
关键词: Crohn's disease ；Innateimmunity ；Acupuncture ；Moxibustion
摘要： 目的探究银杏叶提取物注射液联合奥拉西坦对缺血性脑卒中(IS)患者神经功能、颈动脉狭窄程度及血流动力学的影响,为治疗该病症提供方法。方法选择2018年4月至2021年4月由成都中医药大学附属医院诊治的IS患者162例,根据随机数字表法分为对照组80例和观察组82例,均给予常规西医治疗,在基础上,对照组应用奥拉西坦治疗,观察组应用银杏叶提取物注射液联合奥拉西坦治疗,评价两组患者疗效、神经功能、颈动脉狭窄程度、血流动力学状况、不良反应和预后。结果观察组患者的治疗总有效率显著高于对照组(P<0.05);治疗后,两组患者的美国国立卫生研究院脑卒中量表(NIHSS)评分、血清S-100β蛋白、神经元特异烯醇化酶(NSE)水平、颈动脉斑块面积、颈动脉-中膜厚度(IMT)和颈动脉狭窄比例均显著降低,且观察组低于对照组(P<0.05);治疗后,两组患者颈总动脉和大脑中动脉的收缩期峰值血流速度(PSV)水平均显著提高(P<0.05),血管搏动指数(PI)水平均显著降低(P<0.05),且观察组患者在接受治疗后颈总动脉和大脑中动脉的PSV水平高于对照组(P<0.05),PI水平显著低于对照组(P<0.05);治疗期间,两组患者均未出现严重药物不良反应。结论银杏叶提取物注射液联合奥拉西坦治疗IS疗效确切,在改善患者神经功能和颈动脉狭窄程度等血流动力学方面优势明显,具有一定临床应用价值。
关键词: 老年 ；银杏叶提取物注射液 ；缺血性脑卒中 ；神经功能 ；颈动脉狭窄 ；血流动力学
被引量
3
【期刊论文】 • MU Jie 1ZHANG Shuang 2
+5位作者
• 《Journal of Traditional Chinese Medicine》 CSCD
• 2021年第2期 338 -
348， 共11页
摘要： OBJECTIVE:To investigate the mechanism underpinning the effect of Chaihu Shugan San(柴胡疏肝散,CHSGS)on major depressive disorder(MDD).METHODS:We searched the compound components of from seven herbal ingredients of CHSGS from TCMSP,SymMap,ETCM,NPASS databases,and the chemical structure of the compound from PubChem,and collected the compound targets from TCMSP and TargetNet databases,and MDD-related targets from DiseaseGene Network.We established protein-protein interaction in the STRING database.Through gene mapping,topology analysis and enrichment analysis,the core targets and pathways of CHSGS for MDD,and the involved biological processes(BP),cell components(CC),and molecular functions(MF)were predicted.RESULTS:We collected a total of 1135 CHSGS compounds.After screening by ADME standards and the five rules of Ribinski,we obtained 99 different chemical components with different chemical structures,and related targets of 183 different CHSGS compounds.In the DiseaseGene Network,a total of 740 relevant targets for MDD were collected.Through gene mapping and topological analysis,62 related targets of CHSGS for MDD,24 targets with topological Chinese herbal medicine were obtained.Through enrichment analysis,10 relevant pathways and 3 core pathways were obtained with the involvement of 127 BP,27 CC,and 43 MF.CONCLUSION:There are multiple targets and signaling pathways are involved in the action of CHSGS in the treatment of MDD.
关键词: Depressive disorder,major ；Pharmacology ；Chaihu Shugan San
被引量
11
【期刊论文】 • 张超 1刘永波 2李广晨 2杨周立 2
+5位作者
• 《Science Bulletin》 CSCD
中科院1区
JCR:Q1
• 2024年第11期 1776 -
1797， 共22页
摘要： Undruggable targets typically refer to a class of therapeutic targets that are difficult to target through conventional methods or have not yet been targeted,but are of great clinical significance.According to statistics,over 80%of disease-related pathogenic proteins cannot be targeted by current conventional treatment methods.In recent years,with the advancement of basic research and new technologies,the development of various new technologies and mechanisms has brought new perspectives to overcome challenging drug targets.Among them,targeted protein degradation technology is a breakthrough drug development strategy for challenging drug targets.This technology can specifically identify target proteins and directly degrade pathogenic target proteins by utilizing the inherent protein degradation pathways within cells.This new form of drug development includes various types such as proteolysis targeting chimera(PROTAC),molecular glue,lysosome-targeting Chimaera(LYTAC),autophagosometethering compound(ATTEC),autophagy-targeting chimera(AUTAC),autophagy-targeting chimera(AUTOTAC),degrader-antibody conjugate(DAC).This article systematically summarizes the application of targeted protein degradation technology in the development of degraders for challenging drug targets.Finally,the article looks forward to the future development direction and application prospects of targeted protein degradation technology.
关键词: Undruggables ；Targeted protein degradation ；PROTAC ；Molecule glue ；DAC ；LYTAC
被引量
45
摘要： 目的:探讨以问题为基础的学习(Problem-Based Learning, PBL)在妇产科临床见习教学中的应用效果及对学生综合能力的影响。方法:于2023年9月至2024年6月,选取吉首大学第一附属医院100名五年级临床医学专业妇产科见习生为研究对象,采用随机数字表法分为PBL教学组(n = 50)和传统教学组(n = 50)。课程结束后,通过标准化测验(基础理论与临床病例分析双模块)及匿名问卷调查(涵盖学习动机、临床思维能力等9项指标)评估教学效果。结果:PBL组基础知识得分显著优于传统组(42.6 ± 4.09 vs 32.6 ± 2.69,P Objective: To explore the application effect of problem-based learning (PBL) in clinical clerkship teaching in obstetrics and gynecology and its impact on students’ comprehensive ability. Methods: From September 2023 to June 2024, 100 fifth-year obstetrics and gynecology interns from the First Affiliated Hospital of Jishou University were selected as the research subjects and divided into PBL teaching group (n = 50) and traditional teaching group (n = 50) by random number table method. After the course, the teaching effect was evaluated by standardized tests (basic theory and clinical case analysis dual modules) and anonymous questionnaires (covering 9 indicators such as learning motivation and clinical thinking ability). Results: The basic knowledge score of the PBL group was significantly better than that of the traditional group (42.6 ± 4.09 vs 32.6 ± 2.69, P < 0.001), and the case analysis score was also significantly improved (38.3 ± 2.42 vs 32.9 ± 2.25, P < 0.001). The questionnaire survey showed that the PBL group was significantly better than the traditional group in terms of learning motivation (3.82 ± 0.85 vs 3.22 ± 0.55), teacher-student interaction (3.48 ± 0.68 vs 3.24 ± 0.48), clinical thinking ability (3.58 ± 0.61 vs 3.18 ± 0.54) and course satisfaction (3.98 ± 0.74 vs 3.56 ± 0.88) (P < 0.05). Conclusion: The PBL teaching model can effectively improve the knowledge integration ability, clinical decision-making level and autonomous learning enthusiasm of obstetrics and gynecology interns, and provide empirical support for optimizing the clinical teaching model.
关键词: PBL教学模式 ；妇产科见习 ；临床思维能力 ；教学满意度 ；医学教育改革
摘要： 老年性高血压是老年人常见的心血管疾病之一,其治疗一直是医学领域的关注焦点。中医辩证联合外治法作为一种传统治疗方法,在治疗老年性高血压方面显示出独特的潜力和优势。本研究采用文献综述方法,系统地探讨了中医辩证联合外治法在治疗老年性高血压中的应用研究进展。研究结果显示,中医辩证联合外治法能够显著改善患者的症状和生活质量,并有效降低血压水平。中医辩证治疗强调个体化和整体平衡,通过辨识不同证型如肝阳上亢、阴虚阳亢等,采取相应的治疗手段,如针灸、推拿、拔罐和中药敷贴等。尽管存在研究方法的局限性和对不同证型治疗效果评估的不明确,但中医辩证联合外治法在老年性高血压治疗中显示出显著的临床优势。但中医辩证联合外治法治疗老年性高血压仍缺乏更多的循证医学证据支持,故未来应着重开展该领域的临床研究及基础研究探索。Senile hypertension is one of the common cardiovascular diseases in the elderly, and its treatment has been the focus of medical attention. As a traditional treatment method, TCM dialectical combined external treatment has shown its unique potential and advantage in the treatment of senile hypertension. This study systematically discussed the application of TCM dialectical combined with external treatment in the treatment of senile hypertension by literature review. The results showed that the combination of TCM dialectical treatment and external treatment could significantly improve patients’ symptoms and quality of life, and effectively reduce blood pressure levels. The dialectical treatment of TCM emphasizes individualization and overall balance. By identifying different syndrome types such as liver-yang hyperactivity, Yin deficiency and Yang hyperactivity, corresponding treatment methods are adopted, such as acupuncture, massage, cupping and TCM application. Despite the limitations of the research method and the unclear evaluation of the therapeutic effect of different syndrome types, TCM dialectical combined with external treatment has shown significant clinical advantages in the treatment of senile hypertension. However, the combination of TCM dialectical and external treatment for senile hypertension still lacks more evidence-based medical evidence support, so clinical research and basic research exploration in this field should be emphasized in the future.
关键词: 中医辩证 ；老年性高血压 ；外治法 ；研究进展
摘要： 目的探讨银杏叶片联合奥拉西坦在非痴呆性血管认知障碍(VCIND)患者中应用效果与安全性。方法选取我院VCIND患者102例,随机数字表法分为对照组(n=51)与研究组(n=51)。常规干预基础上对照组采取奥拉西坦治疗2周,研究组于对照组基础上加用银杏叶片治疗3个月。统计两组临床疗效、治疗前及疗程结束后的血清糖基化终末产物受体可溶性片段(sRAGE)浓度、淀粉蛋白前β位分解酶1(BACE1)水平、日常生活能力(ADL)、记忆功能(WMS评分)、认知功能(MoCA)及智力状态(MMSE)评分、局部脑血流量、不良反应(呕吐恶心、头晕、皮疹)发生率。结果在临床疗效方面,研究组总有效率(94.12%)高于对照组(80.39%)(P<0.05);疗程结束后两组血清sRAGE较治疗前增高,BACE1水平较治疗前降低,且研究组sRAGE高于对照组、BACE1低于对照组(P<0.05);疗程结束后两组ADL、WMS、MoCA、MMSE分值较治疗前增高,且研究组高于对照组(P<0.05);疗程结束后两组局部脑血流量较治疗前增大,且研究组大于对照组(P<0.05);研究组不良反应发生率(11.76%)与对照组(7.84%)间无显著差异(P>0.05)。结论联合采取奥拉西坦及银杏叶片治疗VCIND可有效调节血清sRAGE及BACE1水平,改善患者认知功能、记忆功能与智力状态,恢复日常生活能力,增大局部脑血流量,利于提高疾病整体治疗效果。
关键词: 非痴呆性血管认知障碍 ；银杏叶片 ；奥拉西坦 ；sRAGE ；BACE1 ；ADL ；WMS ；MoCA ；MMSE
被引量
1
摘要： 目的研究盐酸多奈哌齐对老年痴呆患者的疗效以及对简易智力状态检查量表(MMSE)评分和日常生活能力量表(ADL)评分的影响。方法选择我院2015年2月—2017年2月收治的90例老年痴呆患者为研究对象,随机将其分为对照组和观察组2组,每组45例。给予对照组患者奥拉西坦治疗,观察组患者则在对照组的基础上加用盐酸多奈哌齐。比较2组患者的治疗效果以及治疗前后的MMSE、ADL评分。结果 2组患者治疗前MMSE评分差异不大,但治疗后,观察组的MMSE评分显著高于对照组(P<0.05);2组患者治疗前ADL评分差异不大,但治疗后,观察组的ADL评分显著高于对照组(P<0.05)。观察组患者治疗总有效率为95.56%,显著高于对照组的75.56%(P<0.05);2组患者均有恶心呕吐、皮肤症状、乏力、失眠等不良反应,但观察组不良反应的总发生率为11.11%,显著低于对照组的31.11%(P<0.05)。结论盐酸多奈哌齐能显著提高老年痴呆患者的认知功能和生活自理能力,降低不良反应发生率,安全性好,可在临床上推广应用。
关键词: 老年痴呆 ；盐酸多奈哌齐 ；奥拉西坦 ；疗效简易智力状态检查量表评分 ；日常生活能力量表评分
被引量
7
摘要： 目的研究胞二磷胆碱联合奥拉西坦治疗新生儿缺氧缺血性脑病的临床疗效。方法选取2016年9月—2018年10月海安市人民医院收治的缺血缺氧性脑病患儿100例纳入此次研究范围,采用数字表法将所有患儿随机分为对照组和治疗组,每组各50例。对照组静脉滴注奥拉西坦注射液,1g加入到5%葡萄糖注射液50m L中,1次/d。治疗组在对照组治疗的基础上静脉滴注胞二磷胆碱注射液,1m L加入到10%葡萄糖注射液30m L中,1次/d。两组患儿均持续治疗2周。观察两组的临床疗效,比较两组的血清学指标、新生儿神经行为(NABA)评分、运动发育指数(PDI)评分和智力发育指数(MDI)评分。结果治疗后,对照组和治疗组的总有效率分别为72.0%、90.0%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患儿血清基质金属蛋白酶-9(MMP-9)和Tau蛋白(Tau)水平均明显降低,脂联素(APN)和胰岛素样生长因子-1(IGF-1)水平均明显增高,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组血清学指标明显优于对照组,两组比较差异有统计学意义(P<0.05)。治疗后,两组患儿NBNA评分显著提高,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组NBNA评分明显高于对照组,两组比较差异有统计学意义(P<0.05)。治疗后90d进行随访,两组患儿PDI评分和MDI评分显著提高,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组PDI评分和MDI评分明显高于对照组,两组比较差异有统计学意义(P<0.05)。结论胞二磷胆碱注射液联合奥拉西坦注射液治疗新生儿缺氧缺血性脑病的疗效确切,可改善血清MMP-9、Tau、APN和IGF-1水平,提升患儿神经行为和智力发育情况,具有一定的临床推广应用价值。
关键词: 胞二磷胆碱注射液 ；奥拉西坦注射液 ；新生儿缺血缺氧性脑病 ；神经功能 ；智力行为 ；血清学指标
被引量
14
摘要： 目的:分析丹红注射液与奥拉西坦联合治疗脑梗塞的临床疗效。方法:随机在某院2015年11月~2016年11月收治的脑梗塞患者中选取112例为研究对象,根据平均分配将其分为对照组与研究组,给予对照组患者丹红注射液治疗,而研究组患者则在丹红治疗的基础上施加奥拉西坦进行联合治疗,对两组患者的治疗效果进行观察与比较。结果:研究组与对照组两组患者治疗后的临床治疗总有效率分别为98.21%与94.64%,两组在治疗总有效率上比较无明显差异(P>0.05);但研究组的治愈率39.29%与显效率42.86%皆明显高于对照组的治愈率28.57%与显效率32.14%(P<0.05);同时治疗后研究组患者的NIM评分(14.51±2.41)分也明显低于对照组患者的(23.64±3.11)分(P<0.05)。结论:应用丹红注射液与奥拉西坦联合治疗脑梗塞患者,对于促进患者神经功能的恢复,提高临床治疗效果具有明显作用,临床应用价值较高。
关键词: 脑梗塞 ；丹红注射液 ；奥拉西坦 ；临床疗效
被引量
5
摘要： 在现代医学教育中,培养具有全面素质的妇科专硕研究生是医学教育的重要目标。本文基于“三全育人”理念,对妇科专硕研究生培养模式现状进行剖析,针对存在的主要问题,提出了“四位一体”的培养新模式,以基础知识、临床技能、科研创新和德政双馨为四大支柱,旨在全面提高妇科专硕研究生的综合素质。本文将逐一剖析现存培养模式的不足并进一步探讨“四位一体”新模式的理论基础和实践应用,以期为妇科医学教育提供新的思路和方法。In modern medical education, it is an important goal of medical education to train gynecological graduate students with all-round quality. Based on the concept of “three-wide education”, this paper analyzes the current training mode of gynecology master students, and puts forward a new training mode of “four-in-one” in view of the main problems, with the four pillars of basic knowledge, clinical skills, scientific research innovation and moral and political integrity, aiming at comprehensively improving the comprehensive quality of gynecology master students. This paper will analyze the shortcomings of the existing training mode one by one and further explore the theoretical basis and practical application of the new mode of “four-in-one”, in order to provide new ideas and methods for gynecological medical education.
关键词: 中医妇科学 ；专硕研究生 ；三全育人 ；四位一体 ；医学教育 ；人才培养
摘要： 目的探讨活血化瘀方联合奥拉西坦对缺血性脑卒中患者认知功能的影响及疗效。方法选择2017年12月~2019年3月在我院诊治疗的缺血性脑卒中患者106例,做为本次研究对象,按照数字表法分为对照组(给予奥拉西坦治疗)和观察组(上述基础上联合活血化瘀方治疗),每组均为53例。采用MoCA认知功能量表、KCCQ生活质量量表对两组认知功能、社会功能、生活能力以及总体健康进行评分比较。结果治疗前两组患者认知功能及生活质量量表比较无差异(P>0.05);治疗后观察组患者认知功能及生活质量量表各项评分均优于对照组,组间比有差异(P<0.05)。结论缺血性脑卒中患者给予观察组治疗,有助于改善其临床疗效及认知功能,提高了患者的生活质量,值得临床上推广及应用。
关键词: 缺血性脑卒中 ；奥拉西坦 ；活血化瘀方 ；认知功能 ；生活质量
摘要： 目的探讨奥拉西坦治疗急性缺血性脑卒中恢复期患者认知功能障碍的疗效。方法78例急性缺血性脑卒中恢复期患者,随机分为研究组与参照组,各39例。两组患者均给予对症治疗,在此基础上,参照组给予吡拉西坦治疗,研究组给予奥拉西坦治疗。比较两组治疗效果;治疗前后神经功能缺损程度与日常生活能力;治疗前、治疗7 d后、治疗14 d后认知功能。结果研究组治疗总有效率92.31%高于参照组的74.36%,差异具有统计学意义(P<0.05)。治疗前,两组患者神经功能缺损程度评分与日常生活能力评分比较,差异无统计学意义(P>0.05);治疗后,研究组神经功能缺损程度评分(7.36±2.36)分低于参照组的(9.04±2.47)分,日常生活能力评分(60.47±8.58)分高于参照组的(56.39±7.94)分,差异具有统计学意义(P<0.05)。治疗前,两组认知功能评分比较,差异无统计学意义(P>0.05);治疗7 d后、治疗14 d后,研究组认知功能评分分别为(14.39±3.09)、(22.46±3.27)分,均高于参照组的(12.26±2.79)、(19.85±3.18)分,差异具有统计学意义(P<0.05)。结论给予急性缺血性脑卒中恢复期患者奥拉西坦治疗,可有效缓解认知功能障碍,提高日常生活能力,具有临床应用和推广的价值。
关键词: 奥拉西坦 ；急性 ；缺血性脑卒中 ；恢复期 ；认知功能障碍 ；疗效
被引量
4
摘要： 目的:分析近6年多囊卵巢综合征随机对照研究特点,为临床应用和未来研究提供参考。方法:检索2019~2024年发表在Web of Science的多囊卵巢综合征随机对照研究,对文献基本要素开展计量学分析。结果:共纳入204篇随机对照研究,尽管2023年相关文献较少,近6年多囊卵巢综合症相关随机对照研究年度发文趋势较为稳定,平均年度发文量为34篇。发文量最多的为中科院分区生殖生物学2区杂志《JOURNAL OF OVARIAN RESEARCH》,近6年共计发表PCOS相关RCT研究10篇。影响因子最高的杂志为《LANCET DIABETES & ENDOCRINOLOGY》,目前影响因子为44分。并进一步对主要结局指标和主要干预措施进行可视化分析。Aim: Analyze the characteristics of randomized controlled studies of polycystic ovary syndrome in the past 6 years, which provides reference for clinical application and future research. Methods: Retrieve the randomized controlled study of polycystic ovary syndrome published in the Web of Science from 2019 to 2024, and carried out a metric analysis of the basic elements of the literature. Results: A total of 204 randomized controlled studies were included. Although there were fewer relevant literature in 2023, the annual trend of published randomized controlled studies on polycystic ovary syndrome in the past 6 years was relatively stable, with an average annual published volume of 34 articles. The largest number of articles is “JOURNAL OF OVARIAN RESEARCH”, a journal of distinct 2 of reproductive biology of the Chinese academy of science, which has published a total of 10 PCOS-related RCT research in the past six years. The journal with the highest impact factor is “LANCET DIABETES & ENDOCRINOLOGY”, with a current impact factor of 44 points. And further visualize and analyze the main outcome indicators and main interventions.
关键词: 多囊卵巢综合征 ；文献计量学 ；随机对照试验
摘要： 慢性硬膜下血肿(Chronic Subdural Hematoma, CSDH)是一种常见的神经外科疾病,其治疗和管理一直是神经外科医生和研究人员关注的焦点。近年来,针对CSDH患者术后复发的影响因素研究逐渐成为热点。随着科学技术的发展,对于CSDH患者术后复发的风险预测模型研究逐渐成为热点。这一研究方向可以通过系统整合患者的临床和影像学资料,致力于更准确地评估患者术后复发的风险,为医生制定个体化治疗方案提供一定的科学依据。首先,术后复发风险预测模型通过收集入院时的基本信息、临床特征和影像学资料,建立了对CSDH患者术后复发的风险的预测模型,能够更全面地评估患者的临床特征,为术后复发的风险评估提供更为精准的数据。为医生提供了更详尽的信息,有助于全面了解患者的病情,从而更好地制定治疗计划。其次,风险预测模型在CSDH患者术后复发的临床诊疗中为临床医生提供了一定的决策支持。通过分析患者的临床特点和影像学表现,模型能够辅助医生判断患者术后复发的风险,为患者家属和医生选择不同的治疗策略提供科学依据。这种个性化的决策支持有助于医生更加精准地制定治疗方案,提高治疗效果和患者的康复率。我们通过对风险预测模型在CSDH患者术后复发临床诊疗中的应用的综述,旨在加深其理解并促进相关风险预测模型在今后临床实际应用中的可能。Chronic Subdural Hematoma (CSDH) is a common neurosurgical condition, and its treatment and management have been a focus for neurosurgeons and researchers. In recent years, the study of factors influencing postoperative recurrence in CSDH patients has gradually become a hotspot. With the advancement of science and technology, research on risk prediction models for postoperative recurrence in CSDH patients has gained increasing attention. This research direction aims to systematically integrate clinical and imaging data of patients to more accurately assess the risk of postoperative recurrence, providing certain scientific basis for doctors to develop individualized treatment plans. Firstly, the postoperative recurrence risk prediction model collects basic information, clinical characteristics, and imaging data at admission to establish a predictive model for the risk of recurrence in CSDH patients, allowing for a more comprehensive assessment of patients’ clinical features and providing more precise data for postoperative recurrence risk evaluation. This offers doctors more detailed information, helping them to fully understand the patient’s condition and better formulate treatment plans. Secondly, risk prediction models provide certain decision support for clinicians in the clinical diagnosis and treatment of postoperative recurrence in CSDH patients. By analyzing patients’ clinical characteristics and imaging findings, the model can assist doctors in assessing the risk of postoperative recurrence, providing a scientific basis for families and doctors to choose different treatment strategies. This personalized decision support helps doctors formulate treatment plans more accurately, improving treatment outcomes and patient recovery rates. Through a review of the application of risk prediction models in the clinical management of postoperative recurrence in CSDH patients, we aim to deepen understanding and promote the potential future clinical application of relevant risk prediction models.
关键词: 慢性硬膜下血肿 ；术后复发 ；风险预测模型 ；影像学资料
摘要： 目的:总结腹泻型肠易激综合征的中医药治疗研究进展。方法:从病因病 机、辨证分型、中药内服法、中医外治法、基础试验研究等5个方面来总结近年来中医药治疗腹泻型肠易激综合征的临床研究进展,同时指出研究中存在的问题。结果与结论:中医药治疗腹泻型肠易激综合征有明显的优势,值得推广应用。Objective: To summarize the progress of TCM treatment of diarrhea type irritable bowel syndrome. Methods: The clinical research progress of TCM treatment in recent years was summarized from the five aspects of etiology, syndrome differentiation, TCM internal administration, TCM external treatment, and basic experiment, and pointed out the problems existing in the research. Results and Conclusion: Traditional Chinese medicine has obvious advantages in treating diarrhea type IBS, which is worth popularization and application.
关键词: 肠易激综合征 ；腹泻型 ；研究进展
摘要： 丹参酮IIA (Tanshinone IIA, TanIIA)是从中药丹参中提取的主要有效成分之一,研究表明其在抗炎、抗氧化、抗肿瘤、心脏保护及神经系统保护方面具有显著的药理活性。本文采用文献计量学的方法,对国内外有关丹参酮IIA的研究进行分析,发现丹参酮IIA的研究是基于2000年至2024年间发表的13,681篇有关丹参酮IIA的文献的计量学分析;该领域发表研究论文最多的国家是中国,美国和澳大利亚,而发表论文最多的机构为中国医科大学,中国科学院和中山大学。丹参酮IIA在心血管疾病和神经系统疾病中的研究文献占比最高,研究类型主要以应用基础研究,临床研究和技术开发为主,出现频率最多的关键词为凋亡,表达,激活,氧化应激,炎症反应等,体现了其在这些领域的研究热度和临床应用价值。丹参酮IIA作为一种具有多重药理活性的中药成分,显示出广泛的临床应用前景,而当前研究的局限性和挑战需要我们在未来的研究中予以重视,通过多学科合作和创新研究方法,共同推动丹参酮IIA在疾病治疗中的进一步应用与发展。Tanshinone IIA (TanIIA) is one of the main active ingredients extracted from the traditional Chinese medicine Danshen, and studies have shown that it has significant pharmacological activities in anti-inflammatory, antioxidant, anti-tumor, cardioprotective and nervous system protection. In this paper, bibliometric methods were used to analyze the studies on tanshinone IIA at home and abroad, and found that the research on tanshinone IIA was based on quantitative analysis of 13,681 articles on tanshinone IIA published between 2000 and 2024. The countries with the most published research papers in this field are China, United States and Australia, while the institutions with the most published papers are China Medical University, Chinese Academy of Sciences and Sun Yat-sen University. Tanshinone IIA has the highest proportion of research literature in cardiovascular diseases and nervous system diseases, and the research types are mainly applied basic research, clinical research and technology development, and the most frequent keywords are apoptosis, expression, activation, oxidative stress, inflammatory response, etc., reflecting its research enthusiasm and clinical application value in these fields. As a traditional Chinese medicine ingredient with multiple pharmacological activities, tanshinone IIA has shown a wide range of clinical application prospects, but the limitations and challenges of current research need to be paid attention to in future research, and jointly promote the further application and development of tanshinone IIA in disease treatment through multidisciplinary cooperation and innovative research methods.
关键词: 丹参酮IIA ；药理作用 ；文献计量学 ；心血管疾病 ；神经保护
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