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美国
投稿预审
Journal of Medicinal Chemistry 中科院1区 JCR:Q1 SCIE CA PubMed JST
发文量 38,863
被引量 2,241,244
影响因子(2025版) 6.579

The Journal of Medicinal Chemistry发表分子结构与生物活性或作用模式之间关系的相关研究。 The Journal of Medicinal Chemistry publishes studies that contribute to an understanding of the relationship between molecular structure and biological activity or mode of action. Some specific areas that are appropriate include the following: Design, synthesis, and biological evaluation of novel biologically active compounds, diagnostic agents, or labeled ligands employed as pharmacological tools. Molecular modifications of reported series that lead to a significantly improved understanding of their structure-activity relationships (SAR). Routine extensions of existing series that do not utilize novel chemical or biological approaches or do not add significantly to a basic understanding of the SAR of the series will normally not be accepted for publication. Structural biological studies (X-ray, NMR, etc.) of relevant ligands and targets with the aim of investigating molecular recognition processes in the action of biologically active compounds. Molecular biological studies (e.g., site-directed mutagenesis) of macromolecular targets that lead to an improved understanding of molecular recognition. Computational studies that provide fresh insight into the SAR of compound series that are of current general interest or analysis of other available data that subsequently advance medicinal chemistry knowledge. Substantially novel computational chemistry methods with demonstrated value for the identification, optimization, or target interaction analysis of bioactive molecules. Effect of molecular structure on the distribution, pharmacokinetics, and metabolic transformation of biologically active compounds. This may include design, synthesis, and evaluation of novel types of prodrugs. Novel methodology with broad application to medicinal chemistry, but only if the methods have been tested on relevant molecules.

  • 主办单位： AMER CHEMICAL SOC
  • 出版地区： WASHINGTON
  • 出版周期： 半月刊
  • 别名： J MED CHEM;J Med Chem;J. Med. Chem.;JOURNAL OF MEDICINAL CHEMISTRY;Journal of medicinal chemistry;药物化学
  • 国际标准连续出版物号/电子版： ISSN 0022-2623 / EISSN 1520-4804
  • 创刊时间： 1963年
  • 曾用名： Journal of medicinal and pharmaceutical chemistry
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激动剂口服生物利用度拮抗剂蛋白质抑制剂接受器生物活性评价配位体激酶类疗效学药物研究开发药学化学抑制剂治疗类似物综合集成评估多肽导数构效关系活度肿瘤

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封面
2026年16期
共：32篇

    • Ali, SaghirTian, XiaochenAnastasio, Noelle C.Cunningham, Kathryn A.Zhou, Jia

      19541-19546

    • Pennington, Lewis D.Clay, Julia M.Hell, Sandrine M.Hesse, Matthew J.Jones, Elizabeth V.McAtee, Rory C.Michels, Theodore D.Qunies, Alshaima'a M.

      19547-19559

    • Hiesinger, KerstinKnapp, Stefan

      19560-19592

    • Hlozek, JasonDuran-Frigola, MiquelElliott-Wong, NicolaStander, RudolfWinks, SusanTuron, GemmaChibale, Kelly

      19593-19600

    • Bach, JordiPerez, DanielEsteve, CristinaLlera, OriolTaboada, LorenaEastwood, Paul R.Gonzalez, JacobPages, LluisLopez, BlancaRamon, RosarioGrau, LauraOrtega, AlbertoGonzalez, AlfredoBiosca, FrancescSerrat, JordiConnolly, StephenFonquerna, SilviaBeswick, PaulGracia, JordiLozoya, EstrellaHuerta, Josep M.Espinosa, SoniaOrellana, AdelinaMaldonado, MonicaPerez-Andres, JuanRodergas Mir, CarlosCalaf, ElenaAlberti, JoanAuli, MarionaCarreno, CristinaCalama, ElenaDe Alba, JorgeMiralpeix, MontserratCalbet, MartaRamis, Isabel

      19601-19632

    • Sadagopan, AnanthanSodhi, AnuragGibson, William J.

      19633-19643

    • Ciaglia, TaniaDi Donato, MarziaDi Sarno, VeronicaSmaldone, GerardinaPellecchia, SofiaDi Matteo, FrancescaNapolitano, ValeriaBoccia, EleonoraSorrentino, CarmelaPepe, GiacomoBasilicata, Manuela GiovannaLauretta, CarmineAquino, GiovannaGiovannelli, PiaGomez-Monterrey, Isabel M.Vestuto, VincenzoMigliaccio, AntimoCampiglia, PietroLauro, GianluigiOstacolo, CarmineBifulco, GiuseppeCastoria, GabriellaFerrer-Montiel, AntonioFernandez-Carvajal, AsiaMusella, SimonaBertamino, Alessia

      19644-19670

    • Cheng, WeiyanWang, NingZhao, LinnanLi, ShashaMiao, RuoyangWang, YueqinLiu, ChunxiaWei, HanTian, Xin

      19671-19689

    • Zheng, JinlingLyu, WeidongKe, YingyingWang, YujueDelville, Marie HeleneYu, ShiwenXu, HaifengLiang, NaChen, TingYin, WeiyangZhang, YanChen, HongfeiLi, Wenjun

      19690-19705

    • Chen, PuStrunk, UlrikeArutyunova, ElenaLu, JimmyChen, Sizhu AmeliaDemmon, SydneyMaplethorpe, CassidyKandadai, Appan SrinivasShields, JustinSaffran, Holly A.Lamer, TessFischer, ConradVan Oers, Tayla J.Turner, ZoeLeong, ParcoIyyathurai, JeganYoung, Howard S.Bai, BingVederas, John C.Nieman, James A.Joyce, Michael A.Tyrrell, D. LorneLemieux, M. Joanne

      19706-19728

    • Hu, YuchenZhou, JunchaoGao, YuhangYu, LeyanChen, BanSu, JiangtaoLi, Hong

      19729-19743

    • Van de Velde, EwoutVan Hauwermeiren, AnoukKaralic, IzetVan Pelt, NataschaMatheeussen, AnFeijens, Pim-BartHendrickx, Sarahda Gama Jaen Batista, Denisede Almeida Fiuza, Ludmila Ferreirado Carmo, Cecilia FariaGirao, Roberson DonolaCranshoff, YevvaDe Baere, SiegridCroubels, SiskaSoeiro, Maria de Nazare CorreiaCaljon, GuyVan Calenbergh, Serge

      19744-19758

    • Lukovic, DesimirObradovic, MilicaJovanovic, IvanMarkovic, Bojana SimovicStojanovic, BojanObradovic, KsenijaStepanovic, JelenaFranich, AndjelaPavlovic, SladjanaGajovic, NevenaJovanovic, MilanBarjaktarevic, AnaJakovljevic, MirjanaMarinkovic, JovanaKostic, IsidoraCorovic, IrfanJurisevic, MilenaZivkovic, MarijaRajkovic, SnezanaStojanovic, Bojana

      19759-19778

    • Taylor, Kimberly S.Czekner, Kerri M.Harland, Aubrie A.Ma, HuiyongDang, Vuong Q.Koehn, Kimberly R. K.Frankowski, Kevin J.Stahl, Edward L.Cameron, Michael D.Bohn, Laura M.Aube, Jeffrey

      19779-19807

    • Truong, Cao-MinhBallester, Pedro J.Taboureau, OlivierTran-Nguyen, Viet-Khoa

      19808-19821

    • Lu, DongYu, XinLin, HanfengCheng, RanZhang, MinYang, BinChen, JingjingLi, FengQi, XiaoliWang, Jin

      19822-19840

    • van den Berg, Richard J. B. H. N.van den Nieuwendijk, Adrianus M. C. H.Liu, BingFerraz, Maria J.Ouairy, Cecile M. J.Ghisaidoobe, Amar T.Ma, Qiangvan den Elst, HansStrijland, AnnekeDonker-Koopman, Wilma E.Verhoek, MarriRijpkema, Koen J.Boot, Rolf G.Wennekes, Tomvan der Marel, Gijsbert A.van Boeckel, Constant A. A.Artola, MartaAerts, Johannes M. F. G.Overkleeft, Herman S.

      19841-19855

    • Barczyk, DominikWarszynska, MartaRepetowski, PawelKuncewicz, JoannaDabrowski, Janusz M.

      19856-19876

    • Yang, LiuxinCheng, YiyuQin, SiJiang, JunZhong, ShiyiBi, XinyueXu, JialiWang, KaiQiu, ShuangLi, Xiang

      19877-19890

    • Knez, DamijanMalinak, DavidMeden, AnzeBenetik, Svit FerjancicPislar, AnjaKohoutova, ZuzanaVondrackova, IvetaPsotka, MiroslavLycka, AntoninPulkrabkova, LenkaSoukup, OndrejSkarka, AdamAndrys, RudolfBrazzolotto, XavierIgert, AlexandreDias, JoseNachon, FlorianDetka, JanTargosinski, FilipHliabovich, DziyanaBrunzelle, Joseph S.Shuvalova, LudmillaSalat, KingaRoy, Saktimayee MitraWatterson, Daniel MartinMusilek, KamilGobec, Stanislav

      19891-19917
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2026年16期

2026年16期

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