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美国
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Journal of Medicinal Chemistry 中科院1区 JCR:Q1 SCIE CA PubMed JST
发文量 37,590
被引量 1,984,417
影响因子(2025版) 6.579

The Journal of Medicinal Chemistry发表分子结构与生物活性或作用模式之间关系的相关研究。 The Journal of Medicinal Chemistry publishes studies that contribute to an understanding of the relationship between molecular structure and biological activity or mode of action. Some specific areas that are appropriate include the following: Design, synthesis, and biological evaluation of novel biologically active compounds, diagnostic agents, or labeled ligands employed as pharmacological tools. Molecular modifications of reported series that lead to a significantly improved understanding of their structure-activity relationships (SAR). Routine extensions of existing series that do not utilize novel chemical or biological approaches or do not add significantly to a basic understanding of the SAR of the series will normally not be accepted for publication. Structural biological studies (X-ray, NMR, etc.) of relevant ligands and targets with the aim of investigating molecular recognition processes in the action of biologically active compounds. Molecular biological studies (e.g., site-directed mutagenesis) of macromolecular targets that lead to an improved understanding of molecular recognition. Computational studies that provide fresh insight into the SAR of compound series that are of current general interest or analysis of other available data that subsequently advance medicinal chemistry knowledge. Substantially novel computational chemistry methods with demonstrated value for the identification, optimization, or target interaction analysis of bioactive molecules. Effect of molecular structure on the distribution, pharmacokinetics, and metabolic transformation of biologically active compounds. This may include design, synthesis, and evaluation of novel types of prodrugs. Novel methodology with broad application to medicinal chemistry, but only if the methods have been tested on relevant molecules.

  • 主办单位： AMER CHEMICAL SOC
  • 出版地区： WASHINGTON
  • 出版周期： 半月刊
  • 别名： J MED CHEM;J. Med. Chem.;药物化学;JOURNAL OF MEDICINAL CHEMISTRY
  • 国际标准连续出版物号/电子版： ISSN 0022-2623 / EISSN 1520-4804
  • 创刊时间： 1963年
  • 曾用名： Journal of medicinal and pharmaceutical chemistry
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Biological EvaluationStructure-Activity RelationshipMedicinal Chemistryin Vitro and in VivoDrug DiscoveryPOTENT INHIBITORSReceptor AntagonistsOrally BioavailableAntiviral ActivityAmerican Chemical SocietyDrug Designin VivoSmall-molecule InhibitorsOrally ActiveBiological ActivityInhibitory ActivityAntitumor AgentsPharmacological EvaluationNovel SeriesMetabolic Stability

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1986年4期
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1986年4期

1986年4期

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