- 首页
- 产品推荐个人精选服务科研辅助服务教育大数据服务行业精选服务学科系列服务产品服务
- 期刊大全
- 充值
- 会员
- 职称材料
- 首页
- 产品服务
- 知识脉络
- 期刊大全
- 充值
- 会员
- 职称材料
智能检索
二次检索
任意字段
在结果中检索
在结果中去除
暂无数据
共
606
条结果 ，以下是1
-
20条
1 / 31
已选:0 清除
批量下载
批量引用
相关度
摘要： 目的:为丹参及其复方制剂用于与微循环障碍有关疾病的治疗提供参考。方法:以"丹参""复方制剂""微循环障碍""临床应用""Salvia miltiorrhiza""Compound preparation""Microcirculatory disturbance""Clinical application"等为关键词,组合查询2008年2月-2018年8月在中国知网、万方数据、PubMed等数据库中的相关文献,主要对丹参及其复方制剂在心、脑、肾、眼等器官与微循环障碍有关疾病的临床应用情况进行论述。结果与结论:共检索到相关文献318篇,其中有效文献70篇。丹参及其复方制剂在改善冠状动脉微循环障碍和治疗脑小血管病、糖尿病肾脏病和糖尿病性视网膜病变等与微循环障碍有关疾病方面具有较好的临床疗效,也可用于治疗过敏性紫癜、突发性耳聋、癌症等与微循环障碍有关的其他疾病。丹参及其复方制剂用于与微循环障碍有关疾病的研究目前以药效观察为主,其作用机制不明确,今后应加强对作用机制的研究。丹参及其复方制剂的质量控制和临床安全性研究也不可忽视,尤其应重视中药注射剂上市后的安全性再评价工作。
关键词: 丹参 ；复方制剂 ；微循环障碍 ；临床应用
被引量
35
摘要： 目的:研究海洋鱼低聚肽复方制剂(Marine Fish Oligopeptide Compound Preparation,MFOCP)降尿酸及其修复肾脏损伤的作用及机制。方法:利用次黄嘌呤和氧嗪酸钾构建高尿酸小鼠模型,造模成功后,采用不同剂量MFOCP干预4周,通过测定高尿酸小鼠血清中的黄嘌呤氧化酶(Xanthine Oxidase,XOD)的活性,尿酸(Uric Acid,UA)、肌酐(Creatinine,Cr)及尿素氮(Blood Urea Nitrogen,BUN)的含量,血清及肾脏组织中炎症因子的含量,肝脏组织中XOD、腺苷脱氨酶(Adenosine Deaminase,ADA)的活性,肾脏组织病理学检测,测定肾脏中尿酸转运和重吸收蛋白的mRNA表达量,评价MFOCP的降尿酸及其修复肾脏损伤的作用。结果:MFOCP低、中、高剂量可显著降低模型小鼠血清中UA含量(P<0.01),XOD的活性(P<0.05)及肾脏组织中炎症因子白细胞介素6(Interleukin-6,IL-6)的含量(P<0.05),可改善模型小鼠肾脏组织病变情况,MFOCP中、高剂量还可显著降低血清中Cr和BUN的含量(P<0.01),显著提高小鼠肾脏组织中有机阴离子转运蛋白2(Organic Anion Transporter 2,OAT2)、三磷酸腺苷结合转运蛋白G(Adenosine Triphosphate Binding Cassette Transporter G2,ABCG2)mRNA的相对表达量(P<0.05)。结论:MFOCP可有效降低高尿酸模型小鼠血清中尿酸水平,修复高尿酸导致的肾脏病理损伤,其作用机制,一方面可通过降低血清中XOD的活性减少尿酸合成;另一方面,可通过调控尿酸转运蛋白OAT2和ABCG2的mRNA表达量促进尿酸的排泄。
关键词: 海洋鱼低聚肽 ；降尿酸 ；黄嘌呤氧化酶 ；尿酸转运蛋白
摘要： 为分析复合酶制剂(Compound enzyme preparation,CEP)对肉牛生长性能、氨气排放及粪中重金属含量的影响。试验将80头体重相近、健康良好的肉牛随机分为4组,每组4个重复,每个重复5头。各组肉牛分别采用基础日粮+0、100、200、300 g/t的复合酶制剂饲料饲喂,并记为CEP0组、CEP100组、CEP200组、CEP300组。试验为期30 d。结果表明,(1)CEP200组肉牛平均日增重显著高于CEP0组(P<0.05),CEP200组肉牛平均日采食量显著高于CEP0组、CEP300组(P<0.05),CEP200组肉牛料重比显著低于CEP0组(P<0.05)。(2)第20天,CEP300组粪样氨气浓度显著低于CEP0组(P<0.05);第30天CEP200组、CEP300组氨气浓度均显著低于CEP0组(P<0.05),且CEP300组氨气浓度显著低于CEP200组(P<0.05)。(3)CEP300组肉牛粪中铜含量显著低于CEP0组(P<0.05),CEP200组、CEP300组肉牛粪中镉含量显著低于CEP0组、CEP100组(P<0.05),CEP300组肉牛粪中铅含量显著低于CEP0组(P<0.05)。综上所述,基础日粮添加200 g/t的复合酶制剂能提高肉牛生长性能;基础日粮添加300 g/t的复合酶制剂能降低氨气排放和粪中重金属含量。
关键词: 复合酶制剂 ；肉牛 ；生长性能 ；氨气排放 ；粪中重金属含量
被引量
5
摘要： 拟通过比较魔芋甘露寡糖(konjac mannan oligosaccharide,KMO)、复合芽孢杆菌(compound bacillus,CB)和复合酶制剂(compound enzyme preparation,CEP)对肉兔生产性能、免疫特性及血液生化指标的影响,筛选更为理想的替抗添加剂。将200只(35±2)日龄、健康状况良好、体重相近的生长期伊拉肉兔随机分为5个处理组,每组5个重复,每个重复8只兔。预试期7 d,正式期35 d。结果表明:CB和CEP组肉兔平均日增重显著高于空白对照组和KMO组(p<0.05);抗生素对照组、CB组和CEP组料重比显著低于空白对照组和KMO组(p<0.05);CEP组肉兔腹泻率和死亡率最低。添加CB、KMO、CEP对肉兔免疫器官指数没有显著影响(p>0.05)。CB、CEP和抗生素对照组血清TP含量高于空白对照组(p<0.05);CB组肉兔血清TC含量显著高于空白对照组和抗生素对照组(p<0.05)。CB组、KMO组、CEP组肉兔血清IgM含量均显著高于空白对照组(p<0.05),CEP组肉兔血清IgM含量显著高于抗生素对照组(p<0.05);CB组、KMO组CEP组血清IgA含量显著高于空白对照组和抗生素对照组(p<0.05)。可见,与饲粮中添加抗生素相比,复合芽孢杆菌和复合酶制剂的饲喂效果更好,二者均可同时提高肉兔生产性能和免疫机能,本试验条件下复合酶制剂的效果最好。
关键词: 魔芋甘露寡糖 ；复合芽孢杆菌 ；复合酶制剂 ；血清指标 ；肉兔营养
被引量
2
摘要： 文章旨在探究复合酶制剂(Compound Enzyme Preparation,CEPs)对梅花鹿生长性能、血清生化指标及养分消化率的影响。试验选择均重(31.46±2.68)kg的健康雄性梅花鹿96头,随机分为4组,每组6个重复,每个重复4头,试验组分别在日粮中添加0、0.8、1.6和3.2 g/kg的CEPs,预饲期14 d,正试期120 d。结果表明,与对照组相比,添加1.6和3.2 g/kg的CEPs梅花鹿末重显著提高5.26%和6.48%(P<0.05),干物质采食量显著提高14.67%和16.48%(P<0.05),添加3.2 g/kg的CEPs梅花鹿平均日增重显著提高23.25%(P<0.05),料重比显著降低5.49%(P<0.05)。与对照组相比,添加1.6和3.2 g/kg的CEPs干物质消化率显著提高(P<0.05),添加3.2 g/kg的CEPs粗蛋白消化率显著提高(P<0.05),添加0.8~3.2 g/kg的CEPs中性洗涤纤维消化率显著提高(P<0.05),添加0.8和3.2 g/kg的CEPs钙消化率显著提高(P<0.05)。添加1.6 g/kg和3.2 g/kg的CEPs后,总蛋白(TP)含量显著提高(P<0.05);添加3.2 g/kg的CEPs血尿素氮(BUN)含量显著降低(P<0.05);添加0.8~3.2 g/kg的CEPs免疫球蛋白G(IgG)含量显著提高(P<0.05)。(结论)添加复合酶(3.2 g/kg)通过促进养分吸收提高梅花鹿生长性能,并对血清指标产生一定积极影响。
关键词: 复合酶制剂 ；梅花鹿 ；生长性能 ；养分消化率 ；血清生化
摘要： 文章旨在研究日粮添加复合酶菌制剂(Bacterial enzyme compound preparation,BECP)对肉鸡生长性能、血清生化指标和免疫功能的影响。试验将同批次孵化的1200羽健康1日龄黄羽肉鸡随机分为4组(BECP0、BECP100、BECP200、BECP300组),每组10个重复,每个重复30羽,试验日粮分别在基础日粮中添加0、100、200和300 mg/kg的BECP,试验为期50 d。试验结果:与BECP0组相比,BECP200和300组肉鸡42 d体重显著提升6.10%和5.38%(P<0.05),50 d体重显著提升6.39%和6.00%(P<0.05)。22~42 d,BECP200和300组肉鸡日增重显著提升8.99%和7.67%(P<0.05),料肉比显著下降8.39%和7.17%(P<0.05);43~50 d,BECP200和300组肉鸡日增重显著提升7.36%和8.07%(P<0.05),料肉比显著下降6.24%和7.66%(P<0.05);1~50 d,BECP200和300组肉鸡日增重显著提升6.54%和6.14%(P<0.05),料肉比显著下降6.06%和5.82%(P<0.05)。BECP200和BECP300组血清球蛋白(Glb)含量、碱性磷酸酶(ALP)活性、总抗氧化能力(T-AOC)能力显著升高(P<0.05),尿素氮(BUN)和乳酸脱氢酶(LDH)活性含量显著下降(P<0.05),BECP100~300组尿酸(UA)和丙二醛(MDA)含量显著下降(P<0.05)。BECP200组胸腺指数显著提高(P<0.05),BECP200和300组肉鸡血清免疫球蛋白A(IgA)和免疫球蛋白G(IgG)含量显著升高(P<0.05)。试验结论:在本试验条件下,补充200和300 mg/kg的复合酶菌制剂能增强肉鸡免疫、提高其生长性能。
关键词: 复合酶菌制剂 ；肉鸡 ；生长性能 ；血清生化 ；免疫
被引量
1
摘要： 目的定量评估马钱子中药复方制剂(Chinese materia medica compound preparation of Strychni Semen,CPSS)单用和与常规化学药联用治疗类风湿关节炎(rheumatoid arthritis,RA)的效益与风险,为其临床合理用药提供参考。方法计算机检索中国知网、维普、万方、中国生物医学文献数据库、Embase、Cochrane Library和PubMed等数据库中CPSS治疗RA的临床随机对照研究(randomized controlled trial,RCT),采用Review Manager 5.3软件进行数据合并,得出各指标效用值。然后,建立CPSS治疗RA的多准则决策分析(multi-criteria decision analysis,MCDA)模型评价体系,并采用Hiview3软件分别计算出CPSS单用和与常规化学药联用的效益值、风险值和效益风险总值。最后,借助Crystal Ball嵌入Excel软件进行蒙特卡洛模拟,计算出2种用药方案效益风险差异的95%可信区间(95%CI)及出现差异的概率,优化评估结果。结果最终纳入27项RCT。MCDA模型量化评估结果显示,CPSS单用的效益低于其与常规化学药联用,效益差为−13[95%CI(−23,−3)],差异大于0的概率为0.47%;但其用药风险显著降低,风险差为26[95%CI(13,42)],差异大于0的概率为100%。当2种用药方案的一级指标效益和风险权重各占50%时,CPSS单用和与常规化学药联用的效益风险总值分别为40和34,差异为6[95%CI(−1,16)],CPSS单用优于其联合常规化学药的概率为94.84%,评价结果稳定。结论CPSS单用或联用常规化学药治疗RA使患者获益明显,可作为RA治疗手段的重要补充。但是,当患者对用药风险接受程度较低时,不建议中西医联合用药。
关键词: 马钱子 ；中药复方制剂 ；类风湿关节炎 ；效益风险评价 ；多准则决策分析
被引量
13
【期刊论文】 • ZENG Rui-xiang 1,2,3ZHOU Yuan-shen 2,3ZHANG Min-zhou 1,2,3
摘要： Angina pectoris(AP)is the most common symptom of cardiovascular diseases,which seriously affects the quality of life in cardiovascular patients.Kuanxiong(KX)Aerosol(宽胸气雾剂),a compound preparation that consists of 5 traditional Chinese medicines:Herba Asari,Rhizoma Alpiniae Officinarum,Lignum Santali Albi,Fructus Piperis Longi,and Borneolum,has been used in the treatment of AP for many years,exhibiting a significant curative effect and less side-effect.For the convenience and comprehensive understanding of KX Aerosol,this review systematically summarizes evidence on KX Aerosol in the treatment of AP including the pharmacological effects of its composition,clinical research,animal experiments,and network pharmacology prediction.Meanwhile,we highlight the research limitation of KX Aerosol at present.This review may guide the clinical application of KX Aerosol and further provide a reference for the research of AP.
关键词: Kuanxiong Aerosol ；angina pectoris ；pharmacology ；clinical application ；network pharmacology
被引量
17
摘要： 目的:回顾性分析院内制剂复方石斛消渴颗粒联合二甲双胍西格列汀治疗气阴两虚型2型糖尿病(T2DM)的临床效果。方法:收集2020年11月至2024年4月于福建中医药大学附属第二人民医院治疗,诊断为气阴两虚证,T2DM的患者80例,对照组和观察组各40例,对照组给予二甲双胍西格列汀,观察组给予复方石斛消渴颗粒联合二甲双胍西格列汀联合治疗,比较两组患者治疗30 d后中医证候、空腹血糖水平(FBG)指标的改善情况;部分患者佩戴血糖监测传感器连续动态监测血糖,记录24 h葡萄糖目标范围内时间、葡萄糖高于目标范围时间、葡萄糖低于目标范围内时间和平均血糖,比较治疗前和治疗三个月两组上述指标的差异。结果:治疗后,观察组患者各项中医证候积分均低于对照组,差异具有统计学意义(P Objective: To retrospectively analyze the clinical effect of compound Dendrobium thirst elimination granules combined with metformin and sitagliptin composite preparation in the treatment of type 2 diabetes mellitus (T2DM) patients with Qi Yin Deficiency. Methods: Treatment at the Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine from November 2020 to April 2024, The diagnosis of qi and Yin two deficiency syndrome, In 80 patients with T2DM, 40 cases each in the control and observation group. The control group was given metformin sitagliptin, the observation group received a combination of compound Dendrobium dequenching granules with metformin sitagliptin. Compare the improvement of TCM syndrome and fasting blood glucose level (FBG) after 30 d of treatment;some patients wear blood glucose monitoring sensors to continuously and dynamically monitor blood glucose, record time in 24 h glucose target range, glucose above target range time, glucose below target range time and mean blood glucose, compare the above indicators before and three months of treatment. Results: After treatment, the TCM syndrome scores of the patients in the observation group were lower than those of the control group, and the difference was statistically significant (P < 0.05);FBG was lower in the observation group, the difference was statistically significant (P < 0.05);the baseline was consistent of two samples before the treatment, After three months of treatment, patients in the observation group had greater glucose reduction and no lower glucose values than the target range, and the glucose volatility was less and more stable. Conclusion: T2DM patients treated with compound Dendrobium granules and metformin sitagliptin could hypoglycemic action and regulate the imbalance of body between Yin and Yang to improve the TCM syndrome.
关键词: 气阴两虚 ；2型糖尿病 ；复方石斛消渴颗粒 ；二甲双胍西格列汀 ；联合治疗
摘要： 采用热熔挤出法制备伏格列波糖口溶膜剂,以拉伸性能和溶化时间为指标,筛选优化处方。结果以聚氧乙烯N10为成膜材料、5%甘油为增塑剂的膜剂可在20 s内溶化,体外溶出行为与已在日本上市的膜剂相似。对正常大鼠蔗糖负荷后高血糖的体内试验表明,自制膜剂与国外膜剂以及国内上市的分散片的降血糖效果相当。
关键词: 伏格列波糖 ；口溶膜剂 ；热熔挤出 ；溶出 ；降血糖
被引量
14
摘要： 目的:探讨荞麦黄酮复方制剂(the flavonoid of buckwheat compound preparation,TFBCP)对2型糖尿病大鼠心肌保护作用及其可能的机制。方法:采用高脂高热量饮食加小剂量链脲佐菌素腹腔注射,建立大鼠2型糖尿病模型。将成模大鼠随机分为5组,每天灌胃给药1次,连续8周,计算心重指数(HWI),超声检测各组大鼠心脏功能,测定空腹血糖(FBG)、血脂、肿瘤坏死因子-α(TNF-α)的水平,光镜下观察心肌组织的形态结构改变和电镜观察心肌超微结构的变化,免疫组织化学法检测心肌组织TNF-α的表达。结果:与正常对照组相比,模型组大鼠FBG、甘油三酯(TG)、总胆固醇(T-CHO)、游离脂肪酸(FFA)、HWI、舒张末期左心室前壁厚度(LVAWT)、舒张末期左心室后壁厚度(LVPWT)、左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)、TNF-α明显升高(P<0.01),而射血分数(EF)、舒张末期左心室内径短轴缩短率(FS)则明显降低。与模型对照组相比,TFBCP高、低剂量组能使FBG、TG、T-CHO、FFA、HWI、LVAWT、LVPWT、LVEDD、LVESD、TNF-α降低(P<0.05,P<0.01),而升高EF、FS(P<0.05,P<0.01),且高剂量组作用更明显。光镜及电镜观察显示:模型组大鼠心肌组织结构异常,高、低剂量的TFBCP均能明显改善上述组织的病理变化。结论:TFBCP对2型糖尿病大鼠心肌病变有一定的保护作用,其机制可能与降低血清糖、调血脂、抑制TNF-α的产生有关。
关键词: 荞麦黄酮复方制剂 ；糖尿病心肌病 ；肿瘤坏死因子-α
被引量
3
摘要： 目的:采用湿法制粒,对伏格列波糖片制备工艺及质量评价进行考察,优化处方工艺。方法:在预试验的基础上,影响因素主要考察崩解剂、黏合剂和润滑剂,以溶出度相似因子(f_(2))作为考察指标,采用正交设计法,优选处方工艺,并对最佳工艺进行验证性实验。结果:最优化的条件为:崩解剂(6%(质量分数)低取代羟丙纤维素),黏合剂(5%(质量分数)羟丙甲纤维素),润滑剂(1%(质量分数)硬脂富马酸钠)。结论:该设计合理,易于操作,自制制剂与参比制剂的溶出行为相似。
关键词: 伏格列波糖片 ；溶出度 ；相似因子
摘要： 目的:研究分析双飞龙复合手术间手术流程优化及扫描安全核查方案和运用效果。方法:选择我院2020年1月~2021年6月期间在双飞龙复合手术间实施手术治疗的55例患者为研究对象,组建流程优化团队,设计“点对点”固定归位法,利用IMRI“四方”安全核查表调整手术流程,优化磁共振医师、巡回护士、麻醉医师以及手术医师访谈流程,评价流程改进效果,比较分析优化流程前后的患者满意度和手术室护理质量。结果:与实施前相比,实施后的病历书写、病房管理、护理记录、基础护理、意外风险处理以及总护理质量评分均较高,差异性显著(P Objective: To study and analyze the optimization of operating room procedures for bilateral flying dragon compound surgery and the application and effects evaluation of the scanning safety verification scheme. Methods: A total of 55 patients who underwent surgical treatment in the bilateral flying dragon compound operating room of our hospital from January 2020 to June 2021 were selected as the research subjects. A process optimization team was formed, and a “point-to-point” fixed positioning method was designed. The IMRI “Four Aspects” safety verification form was used to adjust the surgical procedure. The interview process of MRI physicians, circulating nurses, anesthesiologists, and surgeons was optimized. The effects of process improvement were evaluated, and patient satisfaction and operating room nursing quality before and after process optimization were compared and analyzed. Results: Compared with before implementation, the scores for medical record writing, ward management, nursing records, basic nursing, handling unexpected risks, and overall nursing quality after implementation were higher, and the differences were significant (P < 0.05). Meanwhile, the scores for each surgical preparation time, operating room stay time, preoperative waiting time, operational nursing, service attitude, psychological nursing, medical environment, and health education before and after implementation showed statistically significant differences (P < 0.05). Conclusion: The implementation of the optimization of operating room procedures and the scanning safety verification scheme in the bilateral flying dragon compound operating room can integrate medical resources, optimize human resource allocation, improve work efficiency and nursing service quality, and have promotive value.
关键词: 护理质量 ；双飞龙复合手术室 ；安全核查 ；流程管理 ；磁共振
摘要： 在医疗领域中,结肠镜检查常被视作一项检测结直肠病变的重要和可靠技术,并在诊断与早期治疗相关病变中起到关键作用。实施结肠镜检查前,对肠道进行充分的准备工作是必不可少的,因为如果肠道未被清洁干净,将会对检查结果产生负面的影响。本文综述了复方聚乙二醇和硫酸钾钠镁在肠道准备中的应用及研究进展。In the medical field, colonoscopy is widely regarded as an important and reliable technique for detecting colorectal lesions, playing a crucial role in the diagnosis and early treatment of related pathologies. Adequate bowel preparation prior to colonoscopy is essential, as incomplete intestinal cleansing can adversely affect examination outcomes. This article reviews the application and research progress of compound polyethylene glycol and sodium potassium magnesium sulfate in bowel preparation.
关键词: 复方聚乙二醇 ；硫酸钠钾镁 ；肠道准备
摘要： Countless studies have been devoted to the scientific evaluation of the safety and/or efficacy of botanical natural products.Investigators involved in such studies face a unique set of challenges.Natural products differ from their pharmaceutical counterparts in that they are typically complex mixtures,for which the identities and quantities of components present are not known.To further complicate matters,the composition of these mixtures will vary depending on source material and method of preparation.Investigators conducting clinical trials with complex botanical natural products must choose from a myriad of potential preparations,which may vary greatly in composition.In making such decisions,it is extremely useful to know which components of the mixture are most likely to be responsible for its purported biological activity(the"active constituents").The gold standard approach for identifying active constituents of botanical natural products is bioassay-guided fractionation,in which the mixture is subjected to successive rounds of purification and bioassays until an active compound is identified.Bioassay guided fractionation has historically played a critical role in drug discovery,but is,nonetheless,fraught with challenges.The process is biased towards the most abundant and easily isolatable mixture components,which may not be the most biologically active.Furthermore,if multiple compounds contribute either additively,antagonistically,or synergistically to the observed biological activity of the mixture,activity may be lost upon isolation.As a complementary strategy to bioassay-guided fractionation,our research group has developed untargeted metabolomics strategies to aid in the identification of bioactive mixture components.These strategies involve profiling botanical mixtures using ultraperformance chromatography coupled to high resolving power mass spectrometry.The resulting chemical data is then integrated with biological assay data using biochemometric data analysis strategies.Several case studies will be presented illustrating how this approach can be applied,including for the identification of compounds from the botanical green(Camellia sinensis)that inhibit drug metabolizing enzymes.Such studies are being conducted as part of the Center for Excellence in Natural Product Drug Interaction Studies(Na PDI),which is supported by a cooperative agreement with the National Center for Complementary and Integrative Health,a component of the National Institutes of Health.
关键词: biologically active components ；botanical natural products ；untargeted metabolomics strategies
摘要： 设计并研制了用于实验室处方筛选及少量样品制备的实验室用涂膜机以及中试规模的药膜涂膜干燥机。分别用上述两种装备以流延法制备伏格列波糖口溶膜剂,并进行了膜剂小试到中试的工艺研究和质量评价。结果表明,小试及中试规模得到的膜剂在45 s内全部溶解,3 min内均基本释放完全,物理性能、含量及含量均匀度等指标均满足要求。
关键词: 口溶膜剂 ；实验室用涂膜机 ；药膜涂膜干燥机 ；伏格列波糖
被引量
21
摘要： Metal hydrogen sulfates have been used as efficient reagent in organic chemistry. A broad range of reactions including deprotection, oxidation, C--C, C--N and C--O bond formation and cleavage took place in the presence of these reagents under mild and heterogeneous conditions. β-acetamido ketones are useful intermediate in different organic synthesis due to their polyfunctional nature and presence in several bioactive compounds, here in we report a mild, simple and effective method for the preparation of β-acetamido carbonyl compounds using Zn（HSO4）2 and Co（HSO4）2 as readily available, cheap and nontoxic catalysts.
关键词: “第13届亚洲化学大会” ；论文 ；摘要 ；硫酸
摘要： 目的探讨泽泻提取物(alisma orientale extract,AE)及其复方制剂(compound preparation,CP)(含魔芋粉/左旋肉碱/茶多酚)对高脂饮食肥胖大鼠的降脂作用。方法将80只大鼠随机分为空白组(普通饲料)、模型组(高脂饲料)、AE组及CP组(每组各20只),4周后开始灌胃干预至16周。监测体重及摄食量,检测血清脂质代谢指标总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)、高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)及肝功能指标丙氨酸氨基转移酶(alanine aminotransferase,ALT)、天冬氨酸氨基转移酶(aspartate aminotransferase,AST),为测定肝组织氧化应激水平,检测了超氧化物歧化酶(superoxide dismutase,SOD)、谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-Px)和丙二醛(malondialdehyde,MDA)的含量;同时,为评估炎症反应,测定了肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素-1β(interleukin-1β,IL-1β)和白细胞介素-6(interleukin-6,IL-6)的水平。结果干预后,AE组和CP组较模型组可降低体重增幅(P<0.05)、肝重及肝指数,其中CP组效果更优。两个干预组血清TG、TC、ALT、AST、LDL-C分别降低17.30%~28.10%,HDL-C升高21.50%~24.80%。肝组织SOD、GSH-Px活性提升34.70%~41.20%,MDA含量降低39.40%~45.10%,炎症因子TNF-α、IL-1β、IL-6水平下降32.80%~50.30%。结论泽泻提取物及其复方可有效抑制肥胖大鼠脂质沉积,复方制剂通过协同增效机制,在改善脂代谢紊乱、减轻氧化应激及炎症反应方面更具优势。
关键词: 泽泻 ；水提法 ；泽泻复方 ；脂质代谢 ；氧化应激
摘要： 痛风性关节炎(GA)是人体内嘌呤代谢紊乱和(或)尿酸排泄异常引起的一组代谢性疾病。其发病原因多与饮食结构、蛋白质、糖、脂肪过多摄入有关。临床表现为关节红肿热痛,严重影响患者日常生活,因此对抗GA的药物等的研究较为迫切。西药治疗GA的药物如秋水仙碱等,虽能在短期内缓解疼痛,但是长期使用不良反应明显;与西药相比,中医药治疗GA疗效确切,安全性强,更易被患者接受。近年来,业界开展了大量研究探索中医药通过调控NOD样受体热蛋白结构域相关蛋白3 (NLRP3)信号通路治疗GA的作用机制。但目前尚缺乏关于中医药调控NLRP3通路进而治疗GA的全面系统的总结。本文简单阐述了NLRP3炎症信号通路与GA发生发展的关系和中医对痛风性关节炎的认识及诊疗经验,并总结了中药有效成分、中药复方及其制剂、中医外治干预NLRP3炎症小体治疗GA的最新研究报道,以期为GA发病机制及药物治疗的深入研究提供新思路,为临床上运用中医药防治GA提供依据。Gouty arthritis (GA) is a metabolic disorder of purine metabolism and/or abnormal uric acid excretion in the body. The etiology is related to excessive intake of diet, protein, sugar and fat. Clinical manifestations of joint redness, swelling, heat and pain, seriously affect the daily life of patients, so anti-GA drug research is more urgent. Western medicine for the treatment of GA, such as colchicine, can relieve pain in a short time, but the adverse reactions of long-term use are obvious. Compared with Western medicine, traditional Chinese medicine in treating GA is more effective, safer and more acceptable to patients. In recent years, many researches have been carried out to explore the mechanism of TCM treating GA by regulating the signal pathway of NOD receptor thermoprotein domain related protein 3 (NLRP3). However, there is still a lack of a comprehensive and systematic summary of TCM regulation of NLRP3 pathway to treat GA. In this paper, the relationship between NLRP3 inflammatory signaling pathway and the development of GA, the understanding of TCM and the experience of diagnosis and treatment of gouty arthritis were briefly discussed. And it summarized the latest research reports on the effective components of Chinese herbal medicine, Chinese herbal compound and its preparation, TCM external treatment intervention NLRP3 inflammatory body treatment of GA. It is expected to provide a new idea for the further study of pathogenesis and drug treatment of GA, and provide a basis for the prevention and treatment of GA with TCM.
关键词: 痛风性关节炎 ；中医药 ；信号通路 ；研究进展
摘要： 目的:为有效降解烟叶淀粉和蛋白质,提高烟叶可用性、品质和安全性。方法:对两株分别具有蛋白质和淀粉降解能力的菌株BS1、BS3进行发酵条件的优化及复合菌剂的制备,并对复合菌剂的应用效果进行了评价。结果:菌株BS1的最适发酵条件为:10 g/L可溶性淀粉作为碳源、10 g/L蛋白胨作为氮源、CaCl2作为无机盐,在37℃、pH7、转速为230 rpm/min的条件下发酵24 h,BS1的蛋白酶活性为78.18 U/mL;菌株BS3的最适发酵条件为:10 g/L可溶性淀粉作为碳源、10 g/L酵母粉作为氮源及5 g/L的KNO3作为无机盐,在37℃、pH7、转速为230 rpm/min的条件下发酵24 h,测得BS3淀粉酶活为133.93 U/mL。复合菌剂的最佳配方为:载体为水合硅酸,与发酵液比例为1:5;分散剂为2.00%的六偏磷酸钠;湿润剂为1.00%的烷基糖苷;稳定剂为1.00%的甘油。复合菌剂处理48 h并烘烤后,烟叶淀粉和蛋白质含量分别降低了26.41%和17.14%,还原糖和钾离子含量明显升高,糖碱比、钾氯比升高,烟碱含量降低;烟叶颜色、色度及成熟度更好,叶片油润感强,香气质增加,杂气和刺激性减少。结论:通过发酵条件的优化,提高了BS1和BS3的淀粉酶和蛋白酶活性,制备的复合菌剂有效降低了烟叶的蛋白质和淀粉含量,提升了烤后烟叶的品质,具有较好的应用前景。Objective: To effectively degrade the starch and protein of tobacco leaves and improve the availability, quality and safety of tobacco leaves. Methods: In this study, two strains BS1 and BS3 with protein and starch degradation ability were optimized for fermentation conditions and preparation of complex bacterial agent, and the application effect of the complex bacterial agent was evaluated. Results: The optimal fermentation conditions for strain BS1 are: 10 g/L soluble starch as a carbon source, 10 g/L peptone as a nitrogen source, and CaCl2 as an inorganic salt. The protease activity of BS1 was 78.18 U/mL after 24 hours of fermentation at 37˚C, pH7, and rotation speed of 230 rpm/min. The optimal fermentation conditions for strain BS3 are: 10 g/L soluble starch as a carbon source, 10 g/L yeast extract as a nitrogen source, and 5 g/L KNO3 as an inorganic salt. Fermentation is carried out at 37˚C, pH7, and speed of 230 rpm/min for 24 hours, and the amylase activity of BS3 is measured to be 133.93 U/mL. The optimal formula for the compound bacteria agent is the carrier is hydrated silica, with a ratio of 1:5 to the fermentation broth;the dispersant is 2.00% sodium hexametaphosphate;the wetting agent is 1.00% alkyl glucoside;the stabilizer is 1.00% glycerol. After 48 hours of treatment with compound bacteria agents and baking, the starch and protein content of tobacco leaves decreased by 26.41% and 17.14%, respectively. The content of reducing sugars and potassium ions significantly increased, while the sugar alkali ratio and potassium chloride ratio increased, and the nicotine content decreased. The color, chromaticity, and maturity of tobacco leaves are better, the leaves have a strong oiliness, the aroma quality increases, and the impurities and irritancy decrease. Conclusion: By optimizing the fermentation conditions, the amylase and protease activities of BS1 and BS3 were improved. The prepared compound bacteria agent effectively reduced the protein and starch content of tobacco leaves, improved the quality of cured tobacco leaves, and had good application prospects.
关键词: 烟叶 ；淀粉和蛋白质 ；降解菌 ；复合菌剂
已选:0 清除
批量下载
批量引用
- 1
- 2
- 3
- 4
- 5
- 6
- 31